Health news
Health news top Health news

   Login  |  Register    
Health News Make AMN Your Home PageDiscussion BoardsAdvanced Search ToolMedical RSS/XML News FeedHealth news
  You are here : Health.am > Health Centers > Heart - Neurology -
Viral Reactivation a Likely Link Between Stress and Heart Disease Viral Reactivation a Likely Link Between Stress and Heart Disease

Viral Reactivation a Likely Link Between Stress and Heart Disease

Heart • • NeurologyJan 22, 2013

A new study could provide the link that scientists have been looking for to confirm that reactivation of a latent herpes virus is a cause of some heart problems.

Looking at blood samples from 299 heart patients, researchers at Ohio State University found that those who had suffered a heart attack were the most likely to have inflammatory proteins circulating in their blood compared to patients with less acute symptoms. And having more of one of these proteins in the blood was linked to the presence of antibodies that signal a latent Epstein-Barr virus (EBV) reactivation.

To date, these relationships have been hard to find because scientists have been unable to detect evidence of a virus in diseased areas of the cardiovascular system.

In this study, however, the researchers instead looked for antibodies against a protein that can be produced even when only partial or incomplete reactivation of Epstein-Barr EBV occurs. And when this antibody was detected, it was associated with immune system malfunctions connected to inflammation – a known risk factor for heart disease.

Identifying a solid link between a reactivated virus and heart disease is important because of the prevalence of EBV, a human herpes virus that causes infectious mononucleosis and several different types of tumors. An estimated 95 percent of Americans have been infected with the virus by adulthood, and once a person is infected, the virus remains dormant in the body. It can be reactivated without causing symptoms of illness, but reactivation has potential to create chaos in the immune system.

Stress is a known predictor of reactivation of EBV, meaning virus reactivation could be a mechanism by which stress leads to chronic inflammation and eventually cardiovascular diseases.

“In the big picture, this may help clarify the role these viruses play in heart disease,” said co-author Ron Glaser, director of Ohio State’s Institute for Behavioral Medicine Institute (IBMR) and professor of molecular virology, immunology and medical genetics. “And it makes sense, because we know that some viral proteins can induce inflammation, affecting the lining of blood vessels, so that inflammation is in the right place to function as a significant risk factor for heart disease.”

The patients whose blood was sampled for the study were undergoing angioplasty to clear narrow arteries. Researchers tested their blood for the presence of numerous cytokines – proteins that signal the presence of inflammation – as well as for antibody to an EBV encoded viral protein called dUTPase. This protein is produced early in the process of viral reactivation, and may be present even if signs of the virus itself cannot be detected.

Co-author Marshall Williams, professor of molecular virology, immunology and medical genetics, uses a highly sensitive method to detect these antibodies, and hopes to develop an equally effective technique that could be put to use in clinical laboratories.

Patients who had had acute myocardial infarction – a heart attack – were the most likely to have the highest measures of two cytokines, interleukin-6 (IL-6) and intercellular adhesion molecule 1 (ICAM-1) in their blood compared to patients whose main symptom was chest pain.

Researchers also identified a strong relationship between circulating concentrations of ICAM-1 and detectable antibodies to EBV dUTPase. In fact, the highest values of ICAM-1 were found in patients who had had a heart attack and were positive for the dUTPase protein. A similar trend was seen with IL-6, but the finding could have been attributed to chance.

“This study provides the essential clinical corroboration of this mechanism showing enhanced levels of proinflammatory proteins in the blood of patients with acute coronary events and detectable levels of the EBV-related protein,” said Philip Binkley, professor of cardiovascular medicine and epidemiology at Ohio State and a lead author of the study.

Additional co-authors on this work include Glen Cooke and Amanda Lesinski of the Division of Cardiovascular Medicine; Min Chen and Bryon Laskowski of the IBMR; James Waldman of the Department of Pathology; and Maria-Eugenia Ariza and Deborah Knight of the Department of Molecular Virology, Immunology and Medical Genetics. Co-author Mackenzie Taylor, Binkley and Cooke also are investigators in the Davis Heart and Lung Research Institute.

#

Contact: Philip Binkley, (614) 293-8963; or Ron Glaser, (614) 293-0178;

Written by Emily Caldwell, (614) 292-8310;

Provided by ArmMed Media

Viral Reactivation a Likely Link Between Stress and Heart Disease Bookmark this! Viral Reactivation a Likely Link Between Stress and Heart Disease

RELATED STORIES:


 Comments [ + Post Your Own

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]




We are pleased to let readers post comments about an article. Please increase the credibility of your post by including your full name and email.

All comments are reviewed by our editors before they are posted on the site. Just keep it clean, kids.

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

Please enter the word you see in the image below:


   [advanced search]   
What health info have you recently searched for online?
Disease or condition
Exercise or fitness
Diet, nutrition or vitamins
None of the above


Get free support - Headache Causes, Symptoms, Diagnosis, and Treatment on HeadacheCare.net


Health Centers







Diabetes

















Health news
  


Health Encyclopedia

Diseases & Conditions

Drugs & Medications

Health Tools

Health Tools



   Health newsletter

  





   Medical Links



   RSS/XML News Feed



   Feedback


Add to Yahoo RSS News Feed



Google Reader




Syndicate


This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information:
Verify here.




Activity key to a Dementia sufferer\\s well-being at DementiaToday.net