Better mid-life diet linked to healthy aging

The way women eat in their late 50s and early 60s may have some connection to how well they age later on, according to a new study.

Earlier studies examining the benefits of a healthy diet have typically focused on its link to specific diseases or death. The new report took a big-picture view of healthy aging in general.

Most health conditions develop slowly over many years. So it’s important to look at people’s disease risks over the course of their lives - not just in old age, Cecilia Samieri said.

“Midlife exposures are thought to be a particularly relevant period,” she told Reuters Health in an email. “For example, atherosclerosis in cardiac diseases (and) brain lesions in dementia, start in midlife.”

Samieri is from the Research Center INSERM in Bordeaux, France. She worked on the study with researchers from Brigham and Women’s Hospital and the Harvard School of Public Health in Boston.

Their results were published in the Annals of Internal Medicine.

Better mid-life diet linked to healthy aging The report included 10,670 women who were enrolled in the Nurses’ Health Study, a large, long-term study which began in 1976.

Women included in the new analysis were in their late 50s and early 60s and had no major chronic diseases in the mid-1980s.

All participants filled out two diet questionnaires, one in 1984 and one in 1986. The researchers assigned women scores based on how closely their diets matched a general healthy eating index or a Mediterranean-style diet.

Next, they followed the participants to see how well they aged through 2000, when women were in their 70s.

The researchers defined “healthy aging” as having no major chronic diseases, physical impairment, mental health problems or trouble with thinking and memory.

According to that definition, 1,171 women - or 11 percent - were healthy agers. The rest aged normally.

General diet was measured on a scale from 0 (least healthy) to 110 (healthiest). Healthy agers had an average diet score of 53.2, compared to 50.6 among usual agers.

The Mediterranean diet scale ranged from 0 to 9, with higher scores again reflecting healthier diets. Healthy agers scored an average of 4.5 on that scale, compared to 4.3 for usual agers.

Compared with usual agers, healthy agers were also less likely to be obese or smoke and they exercised more in mid-life. Fewer had high blood pressure and cholesterol.

Women with the highest diet scores were 34 percent to 46 percent more likely to have no chronic diseases or impairment in old age versus those with the worst diets, after other health-related factors were taken into account.

Still, the new study can’t prove diet was responsible for healthy aging, researchers said.

Although it included only women, Samieri said there is no reason to believe that similar associations shouldn’t be observed among both genders.

“We know that a balanced plant-based diet, one similar to the Mediterranean diet, the DASH diet, even MyPlate (from can be heart healthy,” Joan Salge Blake told Reuters Health. She is a spokesperson for the Academy of Nutrition and Dietetics and was not involved in the new study.

Heart disease is the number one killer in America, and being overweight and obese can increase heart risks.

“It’s never too late to improve on your diet and lifestyle,” Salge Blake said.

She suggested eating more whole grains, fruits and vegetables, low-fat dairy, meat and chicken and eating at least two servings of fatty fish per week.

SOURCE: Annals of Internal Medicine, online November 5, 2013


The Association Between Dietary Patterns at Midlife and Health in Aging: An Observational Study

Measurements: Diet quality in midlife was ascertained using the Alternative Healthy Eating Index-2010 (AHEI-2010) and Alternate Mediterranean diet scores, averaged from 2 food-frequency questionnaires (1984 to 1986). “Healthy” aging was defined as survival to 70 years or older with maintenance of 4 health domains: no major chronic diseases or major impairments in cognitive or physical function or mental health.

Results: After multivariable adjustment, greater adherence to the AHEI-2010 (upper vs. lower quintiles) in midlife was related to 34% (95% CI, 9% to 66%; P for trend

< 0.001) greater odds of healthy versus usual aging. Greater adherence to Alternate Mediterranean diet was related to 46% (CI, 17% to 83%; P for trend = 0.002) greater odds of healthy aging. When the 4 components of healthy aging were analyzed separately, the AHEI-2010 and Alternate Mediterranean diet were significantly associated with greater likelihood of no major limitations in physical function and mental health.

Limitations: Residual confounding was possible, although many confounding factors were considered. Bias due to complex patterns of measurement error within diet scores cannot be excluded.

Conclusion: Better diet quality at midlife seems to be strongly linked to greater health and well-being in persons surviving to older ages.

Primary Funding Source: National Cancer Institute, National Institutes of Health.

Cécilia Samieri, PhD; Qi Sun, MD, ScD; Mary K. Townsend, ScD; Stephanie E. Chiuve, ScD; Olivia I. Okereke, MD; Walter C. Willett, MD, DrPH; Meir Stampfer, MD, DrPH; and Francine Grodstein, ScD

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