Interferon Does Not Slow or Stop Progression of Hepatitis C in Certain Patients

	Tweet

Interferon does not slow or halt the progression of chronic hepatitis C and advanced liver disease in patients who haven’t responded to previous attempts to eradicate the disease, a national study in which the Saint Louis University School of Medicine participated has found.

Patients in the trial who were treated with interferon did experience a significant decrease in viral levels and liver inflammation, but the trial unequivocally demonstrated that treatment with long-term pegylated interferon – also called peginterferon – does not prevent the worsening of liver disease in patients who’ve failed prior treatments.

“The results are this study are very clear – long-term therapy with peginterferon for those with chronic hepatitis C is not effective in preventing progression of liver disease for patients who did not respond to an initial course of treatment,” said Adrian Di Bisceglie, M.D., professor of internal medicine at Saint Louis University School of Medicine and chairman of the trial’s steering committee.

“Furthermore, the relatively high rate of liver disease progression – about 30 percent over nearly four years – indicates the potential severity of chronic hepatitis C and emphasizes the importance of the ongoing search for new and more effective treatments,” Di Bisceglie added.

Results of the study were reported by Di Bisceglie at the annual meeting of the American Association for the Study of Liver Disease in Boston this week.

Hepatitis C infects more than 100 million people worldwide and as many as 4 million people in the U.S. It ranks with alcohol abuse as the most common cause of chronic liver disease and leads to some 1,000 liver transplants in the U.S. each year.

The randomized, multi-site study involved 1,050 patients with chronic hepatitis C who’d failed prior treatments to eradicate the infection. All had advanced liver fibrosis – a gradual scarring of the liver that puts patients at risk for progressive liver disease.

The trial assessed whether long-treatment with peginterferon prevented the patients from developing Cirrhosis, liver failure or liver cancer. Roughly half of the patients in the study received 90 micrograms of peginterferon in weekly injections for 3.5 years. The other half, the control group, underwent the same follow-up and care as the treated patients, including liver biopsies, quarterly clinic visits and blood tests.

At the end of the study, while patients treated with interferon did have significantly lower blood levels of the hepatitis C virus and less liver inflammation, 34.1 percent of them had experienced one or more of the following outcomes: excess fluid in the abdomen; brain and nervous system damage; Cirrhosis (for those who did not have it initially); liver cancer; or death. Of patients in the control group, 33.8 percent experienced one or more of the outcomes.

Among treated patients, adverse side effects had caused 17 percent to stop peginterferon after 18 months and 30 percent to stop treatment by the end of the trial.

The study was funded by the National Institutes for Health and Hoffman-La Roche Inc.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious disease.

Source: Saint Louis University Medical Center

RELATED STORIES:
How meningitis bacteria attack the brain   Patients With More Difficult to Treat Forms of Hepatitis C are Half as Likely to Treat the Disease   Cholera epidemic spreads in west, central Africa: U.N.   HK wants info on deadly China meningitis outbreak   Emerging E. coli Strain Causes Many Antimicrobial-Resistant Infections in U.S.   US study links infections in womb to asthma   Pneumonia: Children to miss school   Alligator blood may put the bite on antibiotic-resistant infections   Thousands may have been exposed to vCJD in UK   Arizona death prompts probe for European E.coli link   Discovery Could Aid Fight Against Cystic Fibrosis Infection   Study identifies new way to treat common hospital-acquired infection

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]