Adding fruits and vegetables to the diet may help protect the kidneys of patients with chronic kidney disease (CKD) with too much acid build-up, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).
Western diets that are based in animal and grain products are highly acidic and can lead to metabolic acidosis, when too much acid builds up in the body. This is particularly common in patients with CKD because the kidneys are responsible for removing acid through the urine. Metabolic acidosis can cause rapid breathing, confusion, and lethargy. Severe cases can lead to shock or death.
Alkali supplementation therapy such as bicarbonate is used to treat CKD patients with severe metabolic acidosis, but simply adding more fruits and vegetables - which contain alkali - to the diet might also help.
Nimrit Goraya, MD, Donald Wesson, MD (Texas A&M College of Medicine) and their colleagues tested this by randomizing 71 patients with hypertensive stage 4 CKD to receive added fruits and vegetables or an oral alkaline medication for one year. The treatments were dosed to decrease dietary acid by half.
Among the major findings:
Kidney function was similar between the two groups after one year.
One-year plasma total carbon dioxide (PTCO2) increased in both groups, which is consistent with a lessening of metabolic acidosis. PTCO2 was higher in patients receiving bicarbonate than in those receiving added fruits and vegetables.
Urine measurements of kidney injury were lower after one year in both groups.
Although fruits and vegetables are rich in potassium and might raise blood potassium to dangerous levels, levels did not increase in either group.
Tips for People with Chronic Kidney Disease (CKD)
Choose and prepare foods with less salt and sodium.
Why? To help control your blood pressure. Your diet should contain less than 1,500 milligrams of sodium each day.
Eat the right amount and the right types of protein.
Why? To help protect your kidneys.
Choose foods that are healthy for your heart.
Why? To help keep fat from building up in your blood vessels, heart, and kidneys.
“We showed that by addition of alkali such as bicarbonate or alkali-inducing fruits and vegetables, patients had a favorable response by reduction of urinary kidney injury markers,” said Dr. Wesson. “Our study suggests that these interventions will help maintain kidney health in those with kidney disease,” added Dr. Goraya.
In an accompanying editorial, Muhammad Yaqoob, MD (Bartshealth NHS Trust and William Harvey Research Institute, in London) noted that the study is likely to have a limited impact on clinical practice. “A small group of highly motivated patients wishing to reduce their pill burden through dietary modification may benefit from the results of this study. However, many patients find it difficult to follow a diet high in fruits and vegetables and might therefore be more adherent to a supplement,” he wrote. He added that a large multicenter randomized controlled trial examining the impact of supplemental bicarbonate, with and without dietary intervention, in patients with chronic kidney disease is urgently needed.
Choose and prepare foods with less salt and sodium.
- Buy fresh food more often. Sodium (a part of salt) is added to many packaged foods.
- Use spices, herbs, and sodium-free seasonings in place of salt.
- Check the Nutrition Facts label on food packages for sodium. A Daily Value of 20% or more means the food is high in sodium.
- Try lower-sodium versions of frozen dinners and other convenience foods.
- Rinse canned vegetables, beans, meats, and fish with water before eating.
Eat the right amount and right types of protein.
- Eat small portions of protein foods.
- Protein is found in foods from plants and animals. Talk to your dietitian about how to choose the right combination for you.
Choose foods that are healthy for your heart
- Grill, broil, bake, roast, or stir-fry foods, instead of deep frying.
- Cook with nonstick cooking spray or a small amount of olive oil instead of butter.
- Trim fat from meat and remove skin from poultry before eating.
Study co-authors include Jan Simoni, PhD and Chan-Hee Jo, PhD.
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Founded in 1966, and with more than 13,500 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.