Elderly Diabetes Patients with Very Low Glucose Levels Have Slightly Increased Risk of Death

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A new study of older diabetes patients has found that well-controlled blood sugar levels were associated with a lower risk of major complications such as heart attacks, amputation and kidney disease, but the very lowest blood sugar levels were associated with a small but significant increased risk of death. The study published in the June 2011 issue of the journal Diabetes Care, followed more than 70,000 type 2 diabetes patients from Kaiser Permanente who were over 60 years of age for four years.

Because these findings come from an observational study and not a randomized clinical trial, more research needs to be done to fully understand their clinical implications.

“We saw increased mortality and complications, as anticipated, among those with very high blood sugars, but we also saw a modestly increased risk of death among those with very low levels of blood sugar,” said the study’s lead author Elbert Huang, MD, associate professor of medicine at the University of Chicago. Researchers indicated that the best overall outcomes were found among those with intermediate levels of control

Huang and Andrew Karter, PhD, from Kaiser Permanente Division of Research in Oakland, CA, jointly lead the Diabetes & Aging Study, the largest observational study to assess diabetes in older adults in the United States. The 5-year, NIH-funded study investigates care and health outcomes in older patients with type 2 diabetes in a typical community setting.

Most current guidelines suggest keeping glucose levels for patients with diabetes quite low. For people without diabetes, the normal glucose level - measured by a test called hemoglobin A1C, which reflects the average blood glucose level over the previous three months - is between 4 percent and 6 percent, compared to 6 and higher for patients with diabetes.

Because higher levels are associated with complications from this chronic disease, most recommendations for people with diabetes suggest maintaining an A1C less than 7 percent

“We need more evidence regarding how well the 7-percent guideline, which was based on a 1998 British trial that excluded older patients, applies to patients over the age of 60,” said study co-author Andrew J. Karter, PhD, and the study’s principal investigator at the Kaiser Permanente Division of Research.

Recent studies have raised concerns. In 2008, the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was halted after it showed a higher rate of mortality in older patients who received very intensive glucose-lowering treatments.

“In our study,” said Huang, “we found the best overall outcomes among those with the intermediate levels of control, those with A1Cs below 8 percent but above 6 percent. We observed similar patterns for those in their 60s, 70s, and over 80.”

Finding the optimal A1C target is a balancing act, the authors note. The risk of all complications rose with blood sugar levels, but those with an A1C between 6 and 8 percent had the lowest death rates. While those with very poorly controlled blood sugars - A1C over 10 percent - had the highest rates of death, those with an A1C below 6 were also at a somewhat higher than those with an A1C between 6 and 8 percent.

“We cannot say whether this unexpected finding is due to the very low blood sugar itself, the treatments used to control blood sugars, or to some other factors not directly related to the care of diabetes,” Karter explained. “It may be that the sickest patients at high risk of dying simply had low blood sugars to start with, rather than anything directly associated with the care of diabetes increasing the risk of death.”

“Further research, he added, “will be focused on identifying the mechanisms that underlie the somewhat increased mortality among those with very low A1C.”

Since 1993, researchers involved in the Kaiser Permanente Northern California Diabetes Registry have collected extensive epidemiological data on diabetes care and observed health outcomes. The Diabetes & Aging Study follows patients managed by Kaiser physicians using internal care guidelines that mirror national clinical practice. Patients achieve varying levels of blood sugar control. Such community-based studies complement clinical trials by measuring whether the benefits of treatments measured in an experimental setting are also observed in usual practice settings.

The National Institute of Diabetes, Digestive and Kidney Diseases supported the research. Additional authors include Jennifer Y. Liu, MPH and Howard H. Moffet, MPH, Division of Research, Kaiser Permanente Northern California; and Priya M John, MPH, Section of General Internal Medicine, University of Chicago.

About the University of Chicago Medical Center
The University of Chicago Medical Center, established in 1927, is one of the nation’s foremost academic medical institutions and is consistently recognized as a leading provider of complex medical care, medical education and research in biology and medicine.

About the Kaiser Permanente Division of Research
The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and the society at large. It seeks to understand the determinants of illness and well-being and to improve the quality and cost-effectiveness of health care. Currently, DOR’s 500-plus staff is working on more than 250 epidemiological and health services research projects.

About Kaiser Permanente
Kaiser Permanente is committed to helping shape the future of health care. We are recognized as one of America’s leading health care providers and not-for-profit health plans. Founded in 1945, our mission is to provide high-quality, affordable health care services to improve the health of our members and the communities we serve. We currently serve 8.6 million members in nine states and the District of Columbia. Care for members and patients is focused on their total health and guided by their personal physicians, specialists and team of caregivers. Our expert and caring medical teams are empowered and supported by industry-leading technology advances and tools for health promotion, disease prevention, state-of-the art care delivery and world-class chronic disease management. Kaiser Permanente is dedicated to care innovations, clinical research, health education and the support of community health.

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Source: University of Chicago Medical Center

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