Some Inhalers Double Death Rate In COPD Patients

	Tweet

A new analysis that compares two common inhalers for patients suffering from chronic obstructive pulmonary disease (COPD) finds that one reduces respiratory-related hospitalizations and respiratory deaths, but the other—which is prescribed in the majority of cases—increases respiratory deaths.

The Cornell and Stanford universities’ statistical analysis of 22 trials with 15,276 participants found that common bronchodilators known as anticholinergics (generically named tiotropium and ipratropium) reduced severe respiratory events by 33 percent and respiratory-related deaths by 73 percent, compared with a placebo.

However, the same meta-analysis (which combines the results of the numerous studies) found that regularly inhaled beta-agonists (metaproterenol [Alupent], formoterol [Foradil], salmeterol [Serevent, Advair] and albuterol [Proventil, Ventolin, Volmax and others]) increased the risk of respiratory death more than twofold, compared with a placebo.

Yet only 5 percent of all prescriptions for COPD are anticholinergics, with beta-agonists dominating what doctors prescribe, the researchers report.

The study, now online, will be published in an upcoming issue of the Journal of General Internal Medicine.

COPD is a progressive lung disease characterized by difficulty breathing, wheezing and a chronic cough. Complications include bronchitis and pneumonia. It is often associated with smoking.

“When patients used the anticholinergics, they experienced fewer severe exacerbations requiring hospitalizations and fewer respiratory deaths than those taking only a placebo,” said Edwin Salpeter, the J.G. White Distinguished Professor of Physical Sciences Emeritus at Cornell, who led the statistical analysis in the study. An eminent astrophysicist, Salpeter has more recently focused his attention on medical statistics. “With the beta-agonists, it’s the other way around, where the number of respiratory deaths increased when compared with those who took only the placebo.”

“These results suggest that anticholinergics should be the bronchodilator of choice in COPD,” said Shelley Salpeter, M.D., Edwin Salpeter’s daughter and the lead author. She is a clinical professor of medicine at Stanford’s School of Medicine and a physician at Santa Clara Valley Medical Center in San Jose, Calif. “The long-term safety of beta-agonists in patients with COPD should be addressed.”

A recent meta-analysis by the Salpeters also revealed that beta-agonist inhalers increased both hospitalizations and deaths in asthma sufferers of all ages.

Previous studies have shown that patients with COPD build up tolerance to beta-agonists’ bronchodilator and bronchoprotective effects after regular treatment compared with the first dose.

While beta-agonists may reduce symptoms through bronchodilation, the researchers believe they also promote bronchial inflammation and sensitivity by reducing bronchial protection without any warning of increased symptoms, which can then lead to a life-threatening response.

Cornell University

RELATED STORIES:
Study finds cough drugs no better than sugar syrup   Garlic may ward off…a lung condition   US birth raises asthma risk for Mexican Americans   Sleep apnea ups risk of sudden death at night   Reduction in Respiratory Illnesses in Babies Breastfed Six Months vs. Four   Yoga improves respiratory function   Surprising results from smoke inhalation study   SARS may raise risk of tuberculosis   Lung symptoms not tied to first Gulf War service   Clinical Trial Tests Protein to Reduce Angina Pain   Steroid puffs do not up nonvertebral fracture risk   “Wonder Drugs” May Work Wonders for Pulmonary Arterial Hypertension

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]