Partial sleep deprivation linked to biological aging in older adults
A new study suggests that one night of partial sleep deprivation promotes biological aging in older adults.
Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence. These findings causally link sleep deprivation to the etiology of biological aging, and further supports the hypothesis that sleep deprivation may be associated with elevated disease risk because it promotes molecular processes involved in biological aging.
“Our data support the hypothesis that one night of not getting enough sleep in older adults activates important biological pathways that promote biological aging,” said lead author Judith Carroll, PhD, assistant professor of psychiatry and biobehavioral science at the UCLA Cousins Center for Psychoneuroimmunology in Los Angeles, Calif.
The research abstract was published recently in an online supplement of the journal Sleep and will be presented Wednesday, June 10, in Seattle, Washington, at SLEEP 2015, the 29th annual meeting of the Associated Professional Sleep Societies LLC.
The study group comprised 29 community-dwelling older adults. They were age 61-86 years and 48 percent were male. Participants underwent an experimental partial sleep deprivation protocol over four nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (restricted 3 a.m. - 7 a.m.) and another uninterrupted night of sleep (recovery). Blood samples were obtained each morning to assess PBMC gene expression using Illumina HT-12 arrays.
This study was supported with funding by the UCLA Cousins Center for Psychoneuroimmunology, UCLA, American Sleep Medicine Foundation and the National Institute on Aging (NIA).
Abstract Title: Partial Sleep Deprivation Induces DNA Damage and Senescence in Older Adults
Abstract ID: 0082
Presentation Date: Wednesday, June 10
Presentation Type: Oral Presentation
Presentation Time: 2:00 p.m. to 2:15 p.m.
About SLEEP 2015
More than 5,000 sleep medicine physicians and sleep scientists will gather at SLEEP 2015, the 29th annual meeting of the Associated Professional Sleep Societies LLC (APSS), which will be held June 6-10 at the Washington State Convention Center in Seattle. The scientific program will include about 1,200 research abstract presentations. The APSS is a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.
About the American Academy of Sleep Medicine
Established in 1975, the American Academy of Sleep Medicine (AASM) improves sleep health and promotes high quality patient centered care through advocacy, education, strategic research, and practice standards. With nearly 10,000 members, the AASM is the largest professional membership society for physicians, scientists and other health care providers dedicated to sleep medicine.
American Academy of Sleep Medicine