Scientists discover bacteria that can cause bone infections

	Tweet

Scientists have discovered that a bone infection is caused by a newly described species of bacteria that is related to the tuberculosis pathogen. The discovery may help improve the diagnosis and treatment of similar infections, according to an article published in the October issue of the International Journal of Systematic and Evolutionary Microbiology.

Some rare genetic diseases can make patients susceptible to infections with Mycobacterium species, the bacteria that amongst other diseases, cause tuberculosis and leprosy. These patients often suffer from recurring mycobacterial infections throughout their whole lives. Because of this, researchers are trying to identify unusual species that cause disease in order to improve treatment strategies.

“We isolated an unknown species of bacteria from a 7 year old child who has a genetic immune defect,” said Dr Didi Bang from Statens Serum Institut in Copenhagen, Denmark. “The infection had caused bone lesions and this is where we found the newly described bacteria.”

Mycobacterial infections can be very difficult to treat. The bacteria have unique cell walls that protect them from several antibiotics. As well as being resistant to treatment, they can also survive attack with acids, alkalis and detergents. Most mycobacterial infections can be treated with antibiotics such as clarithromycin and rifamycins, but some species are becoming resistant to these antibiotics, so new drugs for treatments must be developed.

“Initial tests suggested we had found a Mycobacterium. By sequencing some of the bacterium’s genes we showed that we had discovered an undescribed species,” said Dr Bang. “We called the bacterium Mycobacterium arosiense. The name comes from Arosia, the Latin name of the city of Aarhus in Denmark, which is where the bacterium was first found. We showed the position of the new bacterium on the Mycobacterium family tree by sequencing genes and comparing them to related bacteria.”

The new pathogen is closely related to Mycobacterium intracellulare and Mycobacterium avium, which cause a lung disease similar to tuberculosis in people, especially those with weak immune systems such as HIV patients that are immunologically suppressed. It is rod-shaped and grows slowly.

“Mycobacterium arosiense can be killed by several antibiotics in the lab, including clarithromycin and rifamycins. However, resistance to fluoroquinolones and isoniazid was observed,” said Dr Bang. “Little knowledge is available on performing resistance tests on mycobacteria other than tuberculosis.”

“We hope that this discovery will help doctors to diagnose similar diseases in the future and that further investigation may improve the treatment of people with similar infections.”

###

Contact: Lucy Goodchild

44-011-898-81843
Society for General Microbiology

RELATED STORIES:
WHO still searching china lab for SARS ‘smoking gun’   Exposure to worm infection in the womb may protect against eczema, study suggests   Green tea flavonoid may prevent reinfection with hepatitis C virus following liver transplantation   Nine die in Alabama during bacteria outbreak   First SARS human vaccine trial under way in China   Knowledge helps prevent spread of herpes virus   Interferon Does Not Slow or Stop Progression of Hepatitis C in Certain Patients   Drug-resistant tuberculosis rife in China   Measles outbreak kills 76 in northeastern Nigeria   Hepatitis C antibodies may be slow to appear   US study links infections in womb to asthma   Anti-bacterial pillow wins product innovation prize

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]