Anti-aging hormone called Klotho actions explained

	Tweet

Scientists recently discovered an anti-aging hormone called Klotho. Now, a new study shows that this protein acts by increasing the cell’s ability to detoxify harmful reactive oxygen species.

The research appears as the “Paper of the Week” in the November 11 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

The klotho gene, named after the Greek goddess who spins life’s thread, is associated with preventing aging in mammals. The klotho gene product, or Klotho protein, is secreted in the blood and functions as an anti-aging hormone.

A defect in the klotho gene in mice leads to a syndrome closely resembling human aging, while overexpression of the gene extends lifespan in mice.

Now Makoto Kuro-o, assistant professor of pathology at the University of Texas Southwestern Medical Center at Dallas, has discovered one way in which Klotho extends lifespan. Using both cultured cells and transgenic mice, the researchers showed that Klotho increases resistance to oxidative stress.

“Increased longevity is always associated with increased resistance to oxidative stress,” explains Kuro-o. “Oxidative stress causes the accumulation of oxidative damage to important biological macromolecules such as DNA, lipids, and proteins that would result in functional deterioration of the cell, which eventually causes aging.”

“In this study,” says Kuro-o, “we propose that Klotho does its job by increasing the ability of the cell to detoxify harmful reactive oxygen species, thereby increasing resistance to oxidative stress of the body.” The protein acts by turning on an enzyme called manganese superoxide dismutase. This enzyme, found in the mitochondria of the cell, then hydrolyzes harmful superoxide into less harmful hydrogen peroxide.

This research may eventually lead to the development of anti-aging drugs, a long-standing goal of many pharmaceutical companies. “We showed that the anti-aging hormone Klotho confers resistance to oxidative stress in cells and animals,” says Kuro-o. “This means that Klotho protein itself or small molecule mimetics may be potentially useful as anti-aging medicines.”

http://www.asbmb.org/

RELATED STORIES:
Genetic testing in epilepsy—it takes more than 1 gene   Whoever said people were much the same was wrong!   Scientists find gene linked to congenital heart defect   Genetic Abnormalities May Cause Cerebral Palsy   New gene discovery could help to prevent blindness   Gene therapy promising for rheumatoid arthritis   Genes and timing of menopause   Gene linked to aging also linked to Alzheimer’s   Gene may cause retardation of Down’s syndrome   Mother’s stem cells likely key to treating genetic disease before birth   Gene therapy shows promise for Parkinson’s   Genetic mutation wakes families before sunrise

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]