Heart Attack Related Medications

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GENERIC NAME: atorvastatin
BRAND NAME: Lipitor

DRUG CLASS AND MECHANISM: Atorvastatin is an oral drug that lowers the level of cholesterol in the blood. It belongs to a class of drugs referred to as Statins which includes lovastatin (Mevacor), simvastatin, (Zocor), fluvastatin (Lescol0, and pravastatin (Pravachol). All Statins, including atorvastatin, prevent the production of cholesterol by the liver by blocking the enzyme that makes cholesterol, HMGCoA reductase.

They lower total blood cholesterol as well as LDL cholesterol levels. (LDL cholesterol is believed to be the “bad” cholesterol that is primarily responsible for the development of coronary artery disease.) Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. Unlike the other drugs in this class, atorvastatin also can reduce the concentration of triglycerides in the blood. High blood concentrations of triglycerides also have been associated with coronary artery disease. Atorvastatin was approved by the FDA in December of 1996.

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Tablets of 10, 20, and 40 mg.

STORAGE: Tablets should be stored below or at room temperature,
15-30°C (59-86°F).

PRESCRIBED FOR: Atorvastatin is used for the treatment of High cholesterol and triglyceride levels. High blood cholesterol is first treated with exercise, weight loss, and a diet low in cholesterol and saturated fats. When these measures fail to achieve enough cholesterol-lowering, medications such as atorvastatin may be added. The National Cholesterol Education Program (NCEP) has published treatment guidelines for use of these medications. These treatment guidelines take into account the level of LDL cholesterol as well as the presence of other factors that increase the risk for coronary artery disease such as diabetes, hypertension, cigarette smoking, low HDL cholesterol level, and family history of early coronary heart disease. The effectiveness of atorvastatin in lowering cholesterol is dose related, meaning that higher doses reduce cholesterol more. Blood cholesterol determinations are performed at regular intervals during treatment so that adjustments in doses can be made.

DOSING: Atorvastatin is prescribed once daily. Starting doses are 10-40 mg. daily. It may be taken with or without food and at any time of day.

DRUG INTERACTIONS: As with other drugs in this class, the risk of muscle breakdown (see “Side Effects,” below) is increased when atorvastatin is given together with other medications such as cyclosporine (Sandimmune), gemfibrozil (Lopid), erythromycin and Nicotinic Acid.

PREGNANCY: It is not known if atorvastatin affects the fetus if taken during pregnancy. Atorvastatin may be used in pregnancy if the physician feels that its benefits outweigh the potential risks.

NURSING MOTHERS: It is not known if atorvastatin is secreted in breast milk. Therefore, the physician must decide whether to instruct a pregnant woman to continue taking atorvastatin and nursing if the benefits of treatment are judged to outweigh the potential risks, or to discontinue either nursing or atorvastatin if the potential risks are judged to outweigh the benefits.

SIDE EFFECTS: Atorvastatin is generally well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, and headache. Atorvastatin should be used with caution in patients with alcohol or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle inflammation (myositis) and breakdown have been reported with other drugs in this class (HMGCoA reductase antagonists), and it is assumed that this side effect also may occur with atorvastatin. Muscle breakdown causes the release of muscle protein (myoglobin) into the blood and accumulation of the protein in the kidney tubules, resulting in kidney failure.

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Lipitor is used for those who have abnormally High cholesterol levels. When taken together with a low-fat diet, this medicine can effectively reduce LDL cholesterol, commonly referred to as the “bad” cholesterol, triglyceride levels, and total cholesterol, while increasing the HDL, or “good” cholesterol.

Order Lipitor online !
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RELATED STORIES:
What are LDL cholesterol particle size patterns A and B?   Does lowering LDL cholesterol prevent atherosclerosis and heart attacks?   How can a second heart attack be prevented?   Angiotensin converting enzyme inhibitors   Preventing further heart attacks   Cholesterol and The Heart   Heart Attack (Myocardial Infarction)   Coronary angiography and Heart Attack   Heart Attack At A Glance   Heparin and Heart Attack   Diagnosis of heart attacks in women   How is a heart attack diagnosed?

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