Drug-Induced Hypoglycemia

	Tweet

A number of drugs apart from the sulfonylureas can occasionally cause hypoglycemia, especially when ingested in large amounts. These include quinine, quinidine, disopyramide, and salicylates. ACE inhibitors, when taken with antidiabetic drugs, can cause hypoglycemia possibly by improving insulin sensitivity.

Recently, it has been reported that the use of gatifloxacin in diabetic patients is associated with serious hypoglycemic and hyperglycemic reactions.

Ten to 20 percent of patients receiving pentamidine for Pneumocystis jiroveci pneumonia develop symptomatic hypoglycemia, particularly when the drug is administered intravenously.

This apparently is due to lytic destruction of pancreatic B cells, causing acute hyperinsulinemia and hypoglycemia.

It is later followed by insulinopenia and hyperglycemia, which occasionally is persistent. Since other drugs have been found to be as effective in treating Pneumocystis pneumonia, pentamidine administration and its hypoglycemic sequelae are less frequently encountered.

RELATED STORIES:
Nighttime & Exercise Induced Hypoglycemia   Hypoglycemia Prevention and Treatment   Hypoglycemic Syndromes   Hepatic Glycogenolysis and Gluconeogenesis   Normal Glucose Homeostasis   Diagnostic Evaluation of Hypoglycemia   Hypoglycemia Treatment   Hypoglycemia - When to Refer   Hypoglycemia Clinical and Laboratory Diagnosis   Hypoglycemia Pathophysiology   Hypoglycemia Causes   Persistent Islet Hyperplasia (NonInsulinoma Pancreatogenous Hypoglycemia Syndrome)

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]