Starting on 3 drugs at time of diagnosis benefits Type 2 diabetics
Patients with type 2 diabetes fare significantly better if they are started on three medications at the time of diagnosis than if they are prescribed a single drug and have other therapies added later, a San Antonio researcher said June 22 at the 73rd Scientific Sessions of the American Diabetes Association in Chicago. The findings, from a study funded by the association, could revise the way physicians manage the endocrine disease.
Comparison
UT Medicine San Antonio physician Ralph DeFronzo, M.D., chief of the Diabetes Division in the School of Medicine at The University of Texas Health Science Center at San Antonio, presented two-year results from 134 participants studied at University Health System’s Texas Diabetes Institute. Half of the subjects received the triple-therapy regimen while the other half received the conventional regimen recommended by the ADA. The standard regimen begins with a single agent (metformin), adds another (sulfonylurea) when the first agent fails, and then adds insulin injections as needed to control blood glucose after the second agent fails.
Dr. DeFronzo reported that:
Mean hemoglobin A1c, a test that strongly predicts the risk of diabetic blood vessel complications such as blindness, kidney failure, heart attacks, stroke and neuropathy, was 6.0 percent after 24 months in the triple-therapy group, compared to 6.6 percent in the conventional therapy group. (The American Diabetes Association and the European Association for Study of Diabetes recommend a maximum hemoglobin A1c level of 6.5 percent.)
While 42 percent of conventional-therapy participants failed to reach the 6.5 percent goal, only 17 percent of the triple-therapy recipients failed to reach it.
In home blood glucose monitoring, triple-therapy patients showed consistent results within the normal range, whereas patients on conventional therapy registered up and down spikes, many of which were out of the normal range.
Patients on triple therapy lost 2-3 pounds on average after two years while patients on conventional therapy gained 9-10 pounds.
Fifteen percent of patients on triple therapy experienced one episode of hypoglycemia (low blood glucose), while 46 percent of those on conventional therapy had at least one hypoglycemic event.
Core deficits corrected
The triple therapy combines agents that correct two core defects in type 2 diabetes - the inability to respond to insulin normally (insulin resistance), and failure of insulin-secreting beta cells to produce enough insulin. Insulin is the hormone that lowers blood glucose levels. Before the study, Dr. DeFronzo and his colleagues, including co-investigator, Muhammad Abdul-Ghani, M.D., Ph.D., of UT Medicine, hypothesized that the triple therapy would produce a greater, more durable reduction in hemoglobin A1c, reduce the fluctuation in plasma glucose by decreasing both fasting and between-meal glucose levels, and prevent weight gain, which is a side effect of traditional therapy.
How Does Exercise Affect Blood Sugar Levels?
Normally, insulin is released from the pancreas when the amount of sugar (glucose) in the blood increases, such as after eating. Insulin stimulates the liver and muscles to take in excess glucose. This results in a lowering of the blood sugar level.
When exercising, the body needs extra energy or fuel (in the form of glucose) for the exercising muscles. For short bursts of exercise, such as a quick sprint to catch the bus, the muscles and the liver can release stores of glucose for fuel. With continued moderate exercising, however, your muscles take up glucose at up to 20 times the normal rate. This helps lowers blood sugar levels. At the same time insulin levels may drop in anyone not taking insulin so the risks of hypoglycemia or low blood sugar is minimized.
But intense exercise can have the opposite effect and actually temporarily increase your blood glucose levels right after you stop exercising. This is especially true for many people with diabetes. The body recognizes intense exercise as a stress and releases stress hormones that tell your body to increase available blood sugar to fuel your muscles. If you have diabetes you may need to check your sugar after exercise to see if this happens to you.
Is Blood Sugar Ever Too High to Exercise?
Yes. In some cases, you should hold off on exercising if your blood sugar is very high and your body is producing ketones. Ask your doctor about if and when you should hold off on exercise.
Two years of normalcy
Two years into the three-year study, it is clear that the triple therapy is accomplishing these therapeutic goals, and that beta cells are being preserved and the body is being sensitized to insulin. “These drugs are not cures, but patients are basically normal while taking them,” Dr. DeFronzo said. “They are not going to develop the microvascular (blood vessel) complications as long as their blood glucose level remains within the normal range.”
I am a diabetic woman, what kind of problems could diabetes cause to my sex life?
For some women with diabetes, vaginitis (inflammation of the vagina) can be recurrent. Bacterial vaginitis occurs due to yeast infections and thrush is the most common of the conditions.
This can make sex painful, and is heralded by itching or burning sensations.
Cystitis can also be a recurrent problem for women with diabetes.
Furthermore, some evidence indicates that, in a similar way to men being unable to maintain an erection, the woman’s clitoris may fail to respond to stimulation.
3 drugs, 3 mechanisms
The triple therapy consists of metformin, a drug that Dr. DeFronzo helped develop in the 1990s; pioglitazone, a newer class of medication for type 2 diabetes; and exenatide, another newer class of drug. Each drug works by a different mechanism, Dr. DeFronzo said. Conventional therapy is to start the patient on metformin and when the response stops, add a class of medication called a sulfonylurea. When those no longer work, the patient is placed on insulin.
Factors for patients, doctors to weigh
Problems with the conventional approach include weight gain, episodes of hypoglycemia and failure to prevent beta cell failure. The conventional approach is less expensive, however.
“We should tell people which drugs work better,” Dr. DeFronzo said. “The individuals and doctors need to decide whether they can afford the treatment.”
Failure at 10 years out
According to the United Kingdom Prospective Diabetes Study, patients on conventional therapy had an average hemoglobin A1c level of 8.6 percent after a mean of 10 years of follow-up, and nearly two-thirds (65 percent) were on insulin for glucose control.
Hypoglycemia and sex
Hypoglycemia can occur during sex. You may also suffer from a night time hypo as the physical exertions of sex mean that in some ways it makes sense to treat intercourse in a similar way to exercise.
However, testing before and after ‘getting it on’ may not help in setting the right mood(!). How you handle blood sugars around sex will come down to personal preference.
If you have an understanding partner it certainly helps, but how you handle things yourself is also key.
If you’re in a new relationship, it may be tempting not to tell your partner about your diabetes and you may find yourself taking great pains to hide your diabetes. However, your diabetes will emerge sooner or later so it’s best to be open where possible.
If your partner is reassuring, you may have found yourself a great life partner.
The Texas Diabetes Institute, a program of University Health System, is the nation’s largest and most comprehensive center, entirely devoted to diabetes prevention, treatment, education, professional training and the relentless search for a cure. Texas Diabetes Institute is located where it is most needed, on San Antonio’s West Side, where the incidence of diabetes is the highest in the nation.
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About UT Medicine San Antonio
UT Medicine San Antonio is the clinical practice of the School of Medicine at the UT Health Science Center San Antonio. With more than 700 doctors – all School of Medicine faculty – UT Medicine is the largest medical practice in Central and South Texas. Expertise is in more than 100 medical specialties and subspecialties. Primary care doctors and specialists see patients in private practice at UT Medicine’s flagship clinical home, the Medical Arts & Research Center (MARC), located at 8300 Floyd Curl Drive, San Antonio 78229. Most major health plans are accepted, and UT Medicine physicians also practice at several local and regional hospitals. Call (210) 450-9000 to schedule an appointment, or visit http://www.UTMedicine.org for a list of clinics and phone numbers.
About University Health System
University Health System is a nationally recognized academic medical center and network of outpatient health centers, owned by the taxpayers of Bexar County. University Health System is consistently recognized as a leader for going paperless with electronic medical records and is the first public health system in Texas to be designated as Magnet Hospital by the American Nurses Credentialing Center. University Hospital, its 496-bed acute care hospital, is the primary teaching hospital for the University of Texas Health Science Center San Antonio, consistently named Best Regional Hospital U.S. News & World Report and is one of just 15 Level I trauma centers in Texas. University Health System’s Community First Health Plans is the region’s only locally-owned, nonprofit HMO and San Antonio AirLIFE, jointly owned by University Health System, is a national leader in emergency air medical transport.
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