Bone health poor in anorexic girls with depression

• Mental health and Psychiatry news • Sep 26, 2005



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Depression appears to further increase the likelihood that girls with anorexia will develop the bone-thinning disease Osteoporosis, according to a report from Australia.

Individually, both anorexia and Depression have been linked to Osteoporosis. This led Dr. Jerzy Konstantynowicz, from The University of Melbourne and colleagues to think that perhaps that the presence of both disorders would increase the risk of Osteoporosis to a greater extent than anorexia alone.

As they report in the Journal of Clinical Endocrinology & Metabolism, the researchers evaluated bone mineral density (BMD) in 45 girls with Anorexia Nervosa, including 14 who also had Depression.

Anorexia Nervosa is an eating disorder in which a person limits eating, and weighs at least 15 percent less than her ideal weight. It usually is considered a female disorder because at least 90 percent of cases are in young women, but it can occur in men or in older people.

A person with this disorder fears being fat, and may be completely convinced that she is overweight despite what the scale shows or what other people say. To achieve or maintain leanness, she may exercise obsessively or use laxatives. Since a super-restrictive diet requires exquisite control, she may become quite careful, inhibited and controlled in other areas of life. For example, she may retreat from social contacts or may perform ritual behaviors.

Consistent with previous reports, BMD in both groups was reduced compared that seen in the general population, the investigators point out. Moreover, subjects with Depression had significantly lower values than those without Depression.

Further analysis showed that the severity of Depression was independently linked to BMD.

Osteoporosis is a bone disorder. The bones become thinner, lose their strength and are more likely to break. People with osteoporosis have a higher risk of fractures. Their bones can fracture even during everyday movements, such as bending or coughing. Osteoporosis is not a form of arthritis, although it can cause fractures that lead to arthritis.

In the United States, osteoporosis causes more than 1.3 million fractures each year. It is much more common in women than in men because of the hormonal changes that occur during menopause. In people with osteoporosis, the wrist usually is fractured first. This typically occurs between ages 50 and 70 in women. However, hip fractures and fractures of the spine are even more common, especially among people in their 70s.

“To our knowledge, this is the first demonstration of a quantitative association between BMD and Depression in anorexic adolescent girls,” the researchers state.

They say that studies are now needed to see if antidepressants might “alleviate the deficit in BMD.”

SOURCE: Journal of Clinical Endocrinology & Metabolism, September 2005.

Provided by ArmMed Media
Revision date: July 7, 2011
Last revised: by Jorge P. Ribeiro, MD



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