Painkillers not as addictive as feared: study

Fewer than five percent of patients prescribed narcotics to treat chronic pain become addicted to the drugs, according to a new analysis of past research.

The finding suggests that concerns about the risk of becoming addicted to prescription painkillers might be “overblown,” said addiction specialist Dr. Michael Fleming at Northwestern University’s Feinberg School of Medicine.

“If you’re a person that doesn’t have a history of addiction and doesn’t have any major psychiatric problems, narcotics are relatively safe as long as your doctor doesn’t give you too much and uses the right medication,” Fleming, who was not involved in the new study, told Reuters Health.

Some recent research has concluded the same thing, but another expert remained skeptical about the new report because many of the studies it included were not considered the best quality research, and they varied widely in their results.

“I think the jury’s still out” on how worrisome prescription opioid addiction is, said Joseph Boscarino of the Geisinger Clinic in Danville, Pennsylvania, who studies pain and addiction.

Opioid painkillers, which include oxycodone, fentanyl and morphine, have only recently become available for patients with chronic pain, said Boscarino, who was not part of the new study.

In the past, the drugs were almost exclusively reserved for cancer patients and people with short-term pain - on the theory that in the first category of patients the need outweighed the risk, and in the second group, short term use was unlikely to lead to long-term addiction.

“They opened up (to chronic pain patients), and since then there’s been a wave of addiction, especially in the last five years,” Boscarino said.

One recent study found that the number of people diagnosed with a substance abuse problem increased by 70 percent from 2001 to 2009, and doctors suspect the increased popularity of prescription painkillers is a primary driver (see Reuters Health story of October 22, 2012).

Of course, not all these cases reflect patients who are using the drugs as directed - or who even have a prescription to treat chronic pain.

To get a sense of how addictive opioid painkillers are for those patients who do have a prescription, researchers from The Cochrane Collaboration, an independent group that reviews research on medications, collected the results from 17 studies covering more than 88,000 people.

All of the patients had been prescribed opioids to treat chronic pain, and nearly all of them had pain unrelated to cancer.

In 10 of the studies, patients used the painkillers for anywhere from three months to several years, while one study included just short-term use of several days and the others did not report the length of time patients were on the drugs.

Taken together, the studies found that 4.5 percent of people developed a dependency on the painkillers.

“It’s a low percentage,” said Dr. Silvia Minozzi, lead author of the study and a member of the Cochrane Drugs and Alcohol Group in Rome.

Although 4.5 percent was the most common rate of addiction among the studies, Minozzi pointed out there were large differences in the rates each study found - ranging from zero to 31 percent.

For instance, a study by Boscarino and his colleagues that was included in Minozzi’s review found that 25 percent of patients became addicted.

The group of patients Boscarino surveyed had a high rate of alcoholism and illegal drug use, though.

He said the disparities among the various studies could also be a result of how people were surveyed about their behaviors.

“We surveyed the patients about their pain in their homes (where) they were relaxed,” he said. “I think they were more inclined not to try to hide their symptoms.”

Minozzi’s review found that, among the three studies with information on substance abuse, people with a history of drug use were more likely than other patients to develop an addiction to their prescription pain pills.

For most people, addiction “does happen, but it’s not very common,” Fleming told Reuters Health. “But if you give a big bottle of Percocets to someone who has an addiction history, who may or may not be using cocaine and marijuana at the same time, they have pain and maybe they should be treated, but they’re much more likely to get into trouble with that.”

Knowing this can help physicians screen patients to judge who might be the most vulnerable to becoming addicted and get them into the appropriate interventions, he said.

Minozzi noted the fact that her review found a “deficiency of good-quality” studies on this subject, “seems to stand in contrast to the widespread concern of doctors and authorities relating to the prescription of opioids for pain.”

SOURCE: Addiction, online October 18, 2012.


Development of dependence following treatment with opioid analgesics for pain relief: a systematic review

Data were extracted from 17 studies involving a total of 88 235 participants. The studies included three systematic reviews, one randomized controlled trial, eight cross-sectional studies and four uncontrolled case series. Most studies included adult patients with chronic non-malignant pain; two also included patients with cancer pain; only one included patients with a previous history of dependence. Incidence ranged from 0 to 24% (median 0.5%); prevalence ranged from 0 to 31% (median 4.5%).

The available evidence suggests that opioid analgesics for chronic pain conditions are not associated with a major risk for developing dependence.

  Silvia Minozzi,
  Laura Amato,
  Marina Davoli

Article first published online: 18 OCT 2012
DOI: 10.1111/j.1360-0443.2012.04005.x

Provided by ArmMed Media