One-day antiviral treats recurrent genital herpes

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Patient-initiated, single-day treatment with the antiviral drug famciclovir is an effective and well-tolerated treatment for recurrent genital herpes, a new study shows.

“For this to work the medication had to be started within six hours of the development of a recurrence,” Dr. Fred Y. Aoki of the University of Manitoba in Winnipeg, the study’s lead author, told Reuters Health. “That will require in effect an education and empowerment of the patient.”

The current approved regimen for the drug is 125 milligrams twice daily for five days. Other approved antiviral drug regimens include valacyclovir twice daily for three days, and acyclovir five times a day for one day.

Aoki and his team tested the safety and efficacy of 1000 milligrams of famciclovir given twice daily for one day compared to an inactive placebo in 320 patients, who were told to begin taking the drug within six hours of the appearance of symptoms.

Among patients who took the drug, nonaborted lesions—those that went beyond the initial stage—lasted a median of 4.3 days compared to 6.1 days for those on placebo. Both aborted and nonaborted lesions lasted 3.5 days among patients given famciclovir compared to 5.0 days for those on placebo, and 23.3 percent of the patients taking the drug had aborted lesions, compared to 12.7 percent of those on placebo.

Patient-initiated treatment is not a new concept in the management of genital herpes, Aoki pointed out, noting that patients with the condition are typically very willing to take an active part in managing it. “This convenient single-day regimen has the potential for improving patient compliance and satisfaction with therapy,” he and his colleagues conclude.

SOURCE: Clinical Infectious Diseases January 2006.

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