Introduction

The monoclonal gammopathies include those diseases in which there is a proliferation of a single clone of immunoglobulin-forming cells that produce a homogeneous heavy chain, light chain, or complete molecule.…

Introduction

Essentials of Diagnosis

• Defect in terminal differentiation of B cells, with absent plasma cells and deficient synthesis of secreted antibody.
• Frequent sinopulmonary infections secondary to humoral immune deficiency.
• …

Selective IgA deficiency is the most common primary immunodeficiency disorder and is characterized by the absence of serum IgA with normal levels of IgG and IgM; its prevalence is about 1:500 individuals. Most…

Introduction
The primary immunologic deficiency diseases include congenital and acquired disorders of humoral immunity (B cell function) or cell-mediated immunity (T cell function). Most of these diseases are rare, and since they…