The primary immunologic deficiency diseases include congenital and acquired disorders of humoral immunity (B cell function) or cell-mediated immunity (T cell function). Most of these diseases are rare, and since they are genetically determined, are seen primarily in children. Several immunodeficiency disorders affect adults, and are discussed below. The WHO classification of immunodeficiency disorders more often affecting adults is set forth in the accompanying box.
- Primary Immunodeficiency Disorders: Selective IgA deficiency. Common variable immunodeficiency. X-linked agammaglobulinemia. Immunodeficiency with normal serum globulins or hyperimmunoglobulinemia. Immunodeficiency with thymoma.
- Secondary Immunodeficiency Disorders (for example, AIDS)
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Fischer A: Human primary immunodeficiency diseases: a perspective. Nat Immunol 2004;5:23.
Revision date: June 20, 2011
Last revised: by Janet A. Staessen, MD, PhD