Tacrolimus effective for skin allergy in kids

Treatment with an ointment containing tacrolimus, an immune-suppressing drug, relieves mild-to-moderate Eczema in children, according to a report in the journal Pediatrics.

Tacrolimus has previously been shown effective in treating moderate-to-severe Eczema in children as young as 2 years of age and to be safe and effective for up to 4 years, the authors explain.

Dr. Lawrence A. Schachner from University of Miami and colleagues compared tacrolimus with inactive “placebo” as a treatment for mild-to-moderate Eczema in 317 pediatric patients.

Tacrolimus was successful in 50 percent of the children, whereas placebo was successful in just 26 percent, the authors report. Nineteen percent of the tacrolimus-treated patients were clear or almost clear of their skin allergy as early as day 4, the results indicate. In contrast, only 12 percent of patients treated with placebo responded so well.

Similarly, the improvement in the eczema area and severity scores by day 4 was significantly greater for the Tacrolimus group than for the placebo group, the researchers note.

Side effects were reported no more often in the tacrolimus group than in the placebo group, the investigators report.

“This study demonstrates that tacrolimus ointment...has a rapid onset of action and can be used safely and effectively for treating mild-to-moderate (eczema) in pediatric patients,” Schachner’s team concludes.

Tacrolimus “provides a steroid-free alternative to traditional (eczema) treatment in pediatric patients,” the researchers add.

SOURCE: Pediatrics, September 2005.

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