Male Sexual Dysfunction
Physiology of Penile Erection
Innervation of the Penis
The autonomic spinal erection center is located in the intermediolateral nuclei of the spinal cord at levels S2-S4 and T12-L2. Nerve fibers from the thoracolumbar (sympathetic) and sacral (parasympathetic) spinal segments join…
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Signal Transduction in Penile Erection
During sexual stimulation, NO released from nerve ending and endothelium diffuses into the trabecular and arterial smooth-muscle cells to activate guanylyl cyclase, which catalyzes the formation of second messenger cyclic guanosine monophosphate (cGMP) (Trigo-Rocha et al, 1993). cGMP…
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Hormones & Sexual Function
Androgens are essential for male sexual maturity. Testosterone regulates gonadotropin secretion and muscle development; dihydrotestosterone mediates all other aspects of male sexual maturation, including hair growth, acne, male pattern baldness, and spermatogenesis. In adults, androgen deficiency results in…
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Male Sexual Dysfunction Introduction
by Tom F. Lue, MD
A better understanding of male sexual dysfunction has been made possible by innovative laboratory and clinical research in the mechanism, neurophysiology, and pharmacology of penile erection. Erectile function can now…
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