Treatment-Resistant Mood Disorders
Bipolar Depressive Subtypes, Other Clinical Factors, and Treatment Response
Bipolar Depressive Subtypes, Other Clinical Factors, and Treatment Response
Although pharmacotherapy with lithium is an effective…
Treatment-Resistant Mood Disorders - Conclusions
Conclusions
Treatment resistance is not a unitary phenomenon but in mood disorders reflects issues of diagnostic…
Multiphase Treatment Strategy for Bipolar Disorder
Appendix: Multiphase Treatment Strategy for Bipolar Disorder
See Figure 45-4 and…
Treatment-Resistant Unipolar Depression
Treatment-Resistant Unipolar Depression
Definition
Systematic integration of available data on clinical management is…
Treatment-Resistant Bipolar Disorder - Practical Management
Practical Management
Management of patients with treatment-resistant bipolar disorder is complicated by the need to be…
Treatment of Bipolar Depression
Treatment of Bipolar Depression
The algorithm presented for treatment-resistant bipolar depression (
Treatments to Control Cycling
Treatments to Control Cycling
As noted earlier, for about 90% of bipolar disorders, recurrence rather than…
Treatment-Resistant Unipolar Depression - Other Treatment Options
Other Treatment Options
Sleep Deprivation
Sleep deprivation to treat depression was first proposed by…
Treatment-Resistant Unipolar Depression Treatment Switching Strategies
Switching Strategies
When patients do not respond to treatment with one antidepressant, a common clinical strategy…
Treatment-Resistant Bipolar Disorder
Treatment-Resistant Bipolar Disorder
Definition
Treatment of bipolar illness involves four primary aims: treatment…
Treatment-Resistant Unipolar Depression Treatment - SSRI-nefazodone combination
SSRI-nefazodone combination To date, only anecdotal reports have suggested the efficacy of combining SSRIs with nefazodone—typically at 100…
Treatment-Resistant Unipolar Depression Treatment - Combined SSRIs and TCAs
Combined SSRIs and TCAs The strategy of combining fluoxetine or other SSRIs with a TCA in the treatment…
Treatment-Resistant Unipolar Depression Treatment - Combined MAOIs and TCAs
Combined MAOIs and TCAs Although in the 1960s combined antidepressant therapy with MAOIs and TCAs was more common,…
Treatment-Resistant Unipolar Depression Treatment - Combined Antidepressant Treatments
Combined Antidepressant Treatments
How should antidepressants be combined and for how long? The term combination strategy…
Treatment-Resistant Unipolar Depression Treatment - Venlafaxine augmentation
Venlafaxine augmentation There are only anecdotal reports of venlafaxine augmentation (75-300 mg/day) in SSRI nonresponders. One disadvantage…
Treatment-Resistant Unipolar Depression Treatment - Higher-Dose Antidepressants
Higher-Dose Antidepressants
What clinical trial evidence for the use of higher-dose antidepressants in treatment-refractory depression is…
Treatment-Resistant Unipolar Depression Treatment - Buspirone augmentation
Buspirone augmentation One relatively user-friendly strategy is buspirone augmentation. Buspirone is typically a well-tolerated anti-anxiety drug, an azaspirodecanedione…
Treatment-Resistant Unipolar Depression Treatment - Dopaminergic and stimulant augmentation
Dopaminergic and stimulant augmentation Dopamine has received less attention than either serotonin or noradrenaline as a factor in…
Antidepressant Treatment Options
Treatment-Resistant Unipolar Depression: Antidepressant Treatment Options
If a depressed patient does not respond to an antidepressant…
Treatment-Resistant Unipolar Depression Treatment - Thyroid augmentation
Thyroid augmentation The addition of thyroid hormone to an antidepressant in antidepressant nonresponders has been reported since the…
Depressive Subtypes and Treatment Response
Treatment-Resistant Unipolar Depression: Depressive Subtypes and Treatment Response
Since the introduction of TCAs in the 1950s,…
Treatment-Resistant Mood Disorders
Introduction
Maurizio Fava, M.D.
Andrew A.…
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