Effects Of Chemoradiation Therapy By Using Capecitabine On Gastric Cancer Patients

	Tweet

Gastric cancer is a major cause of cancer deaths in the world. The outcome of large gastric tumors and those with lymph node involvement remains poor after surgical resection. The optimal adjuvant therapy after surgical resection remains to be determined. The most common strategies in the adjuvant treatment of gastric cancers include fluoropyrimidine-based chemotherapy with or without radiation. The introduction of capecitabine has largely replaced continuous-infusion 5-fluorouracil (5-FU) owing to its ease of administration. However, its efficacy is not proven in randomized phase III trials involving gastric cancers.

A research article published on August 7, 2010 in the World Journal of Gastroenterology addresses this question. In this retrospective review study, the authors examined the role of capecitabine with radiation and compared its efficacy to the 5-FU with radiation regimen and fluoropyrimidinebased chemotherapy alone.

This study showed that capecitabine with concurrent radiation was as effective as 5-FU with radiation or fluoropyrimidine-based chemotherapy alone without radiation when given as adjuvant treatment for locally advanced gastric cancer.

The result from this hypothesis-generating study provides the basis for a further prospective study in evaluating the role of radiation with concurrent capecitabine as adjuvant therapy in resected gastric cancers.

Reference: Tham CK, Choo SP, Poon DYH, Toh HC, Ong SYK, Tan SH, Wang MLC, Foo KF. Capecitabine with radiation is an effective adjuvant therapy in gastric cancers. World J Gastroenterol 2010; 16(29): 3709-3715

Source:
Ye-Ru Wang
World Journal of Gastroenterology

RELATED STORIES:
Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut   Takeda drug impresses in ulcerative colitis study   Biomarkers can reveal IBS   How probiotic bacteria protect against inflammatory bowel diseases   Laparoscopy reduces the risk of small-bowel obstruction   Soy protein alleviates symptoms of fatty liver disease   Newly Approved Treatment for Acid Reflux Disease Available   Rectal NSAID Cuts Pancreatitis Risk After ERCP   Longer treatment with cancer drug following removal of GI tumor results in improved survival   Detection and treatment for hepatic encephalopathy prevents car accidents, reduces costs   Some drugs less harsh than others for IBS: study   Prevention of Aspirin-Related Gastric Ulcers   Pozen rises as ulcer drug meets goals in studies   Colonoscopy Patients Opt for Painless Approach   Researchers Find 5 Risk Biomarkers for Crohn’s Disease In Jews of Eastern European Descent

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]