New combination therapy looks promising against ulcer bacteria

Helicobater pylori, a bacteria implicated in peptic ulcers and gastritis, was eradicated in 95 percent patients who took a 7-day course of combination therapy with levofloxacin, omeprazole, nitazoxanide (Alinia®) and doxycycline (LOAD) compared to eradication in only 80.9 percent of patients on lansoprazole, amoxicillin and clarithromycin (LAC) for seven days.

Results of a new study presented at the Annual Scientific Meeting of the American College of Gastroenterology reveal LOAD therapy is superior to LAC at eliminating the bacterium in patients with gastritis and peptic ulcers. Moreover, Dr. Patrick Basu and his colleagues at Columbia University College of Physicians and Surgeons found that a shorter course of the four-drug combination, seven days vs. a ten-day treatment, is equally effective.

The study included 135 patients with treatment naïve Helicobacter pylori infection who were randomized to LOAD (7 or 10 days) vs. LAC (10 days). There was a total wash out period of six weeks from any prior antibiotic and PPI use prior to the initiation of therapy.

"H. pylori gastritis is a global threat for gastric carcinoma and many therapies have been explored to eradicate this infection with variable success rates,” explained Dr. Basu. “Our study demonstrates the therapeutic superiority of LOAD therapy over LAC therapy in a treatment naïve population of patients with H. pylori.”

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About the American College of Gastroenterology

Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of more than 11,000 individuals from 80 countries. The College is committed to serving the clinically oriented digestive disease specialist through its emphasis on scholarly practice, teaching and research. The mission of the College is to serve the evolving needs of physicians in the delivery of high quality, scientifically sound, humanistic, ethical, and cost-effective health care to gastroenterology patients. http://www.acg.gi.org

View releases on other research breaking at the ACG meeting at http://www.acg.gi.org/media/press.asp

Contact: Jennifer Burke Labriola

203-405-1479
American College of Gastroenterology

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