Effects of HIV-1 on the Nervous System

Effects of HIV-1 on the Nervous System
Several disorders have been suggested to relate in a more direct or fundamental way to HIV-1 infection. These include the AIDS dementia complex, aseptic meningitis, and perhaps predominantly sensory neuropathy. Although considerable uncertainty still exists regarding their pathogenesis, the uniqueness of these conditions in HIV-1-infected compared with other immunosuppressed patients, as well as more direct evidence of virus infection in some patients with the AIDS dementia complex, lends support to this contention.

Diagnosis: Neuroanatomic Approach
As with other neurologic disease, diagnosis in AIDS patients begins with localization of symptoms and signs and hence involves neuroanatomic classification (Table 411-2) .

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Revision date: June 14, 2011
Last revised: by Sebastian Scheller, MD, ScD