Health news
Health news top Health news

   Login  |  Register    
Health News Make AMN Your Home PageDiscussion BoardsAdvanced Search ToolMedical RSS/XML News FeedHealth news
You are here : Health.am > Health Centers > HIV/AIDS Health CenterHIV/AIDS news

Mechanism of HIV spread has potential for future drug therapy

HIV/AIDS newsApr 23, 2012

A new understanding of the initial interactions of human immunodeficiency virus type 1 (HIV-1) and dendritic cells is described by Boston University School of Medicine (BUSM) researchers in a study currently featured in the Proceedings of the National Academy of Sciences (PNAS). With over 2.5 million new HIV infections diagnosed annually and earlier detection becoming more common, better understanding of early virus-host interactions could have a great impact on future research and drug therapy.

In this study, the researchers describe a novel mechanism of HIV-1 spread by dendritic cells. These cells, which are present at the body’s mucosal surfaces, are the focus of research because they are among the first cells to encounter HIV-1 and trigger the immune system. While previous work has focused on the HIV-1 envelope glycoprotein method of interactions, this research details the role of a molecule called GM3, which arises from the host itself and is used by the virus for attachment and spread.

Since this virus invasion method depends on the molecules originating from the host, “it is a stealth entry mechanism, likely not detected by the cell, so HIV can spread quickly,” says Dr. Rahm Gummuluru, associate professor in the department of microbiology at BUSM and senior author of the study.

Despite the cleverness of the virus, this unique contact between HIV-1 and dendritic cells may offer a new direction for anti-viral therapies. “Resistance to therapy, which often challenges physicians, is unlikely to occur in drugs that target this interaction, as these drugs would have the benefit of acting on the host, instead of the virus,” Gummuluru. Further research in this field may identify specific targets and offer hope for preventing HIV infections.
###

The research was led by Dr. Wendy Blay Puryear, post-doctoral fellow in the department of microbiology at BUSM, in collaboration with Dr. Björn Reinhard, assistant professor of chemistry and the photonics center at Boston University.

###

Gina DiGravio
.(JavaScript must be enabled to view this email address)
617-638-8480
Boston University Medical Center

Provided by ArmMed Media

Email this to a friend Bookmark this! Printable Version

RELATED STORIES:


 Comments [ + Post Your Own

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]




We are pleased to let readers post comments about an article. Please increase the credibility of your post by including your full name and email.

All comments are reviewed by our editors before they are posted on the site. Just keep it clean, kids.

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

Please enter the word you see in the image below:


   [advanced search]   
UrologyToday.net


Health Centers

Articles & Resources

  What Is AIDS?

  AIDS/HIV Symptoms

  Symptoms and phases

  AIDS HIV Prevention

  AIDS HIV Detection

  Transmission of HIV

  Sexual acts Transmission

  Acute HIV infection
For professionals

Introduction to HIV and Associated Disorders

Immunology Related to AIDS

Biology of Human Immunodeficiency Viruses

Epidemiology of HIV infection and AIDS

Prevention of HIV infection

Neurologic Complications of HIV-1 Infection

Pulmonary Manifestations of HIV Infection

Gastrointestinal Manifestations of AIDS

Cutaneous Signs of AIDS

Ophthalmologic Manifestations of AIDS

Hematology/Oncology in AIDS

Renal, Cardiac, Endocrine, and Rheumatologic Manifestations of HIV Infection

Treatment of HIV infection and AIDS

Management and Counseling for persons with HIV infection


Health Centers





Diabetes









Health news
  


Health Encyclopedia

Diseases & Conditions

Drugs & Medications

Health Tools

Health Tools



   Health newsletter

  





   Medical Links



   RSS/XML News Feed



   Feedback






Add to Google Reader or Homepage
HIV and AIDS News, Headlines and Latest Stories on Health.am
Add to My AOL