Causes of Male infertility

Key points
- The causes underlying male infertility are numerous but are conveniently grouped by effects at one or more of the following levels: pretesticular, testicular, and posttesticular.
- Conditions that cause infertility that act at the pretesticular level tend to be hormonal in nature (Table 42-11).
- Gonadotropin Deficiency (Kallmann Syndrome) Kallmann syndrome is a rare (1:50,000 persons), genetically heterogeneous disorder that occurs in familial and sporadic forms.
- The X-linked form of the disease is a consequence of a single gene deletion (Xp22.3 region, termed KALIG-1).
The causes underlying male infertility are numerous but are conveniently grouped by effects at one or more of the following levels: pretesticular, testicular, and posttesticular.
Pretesticular
Conditions that cause infertility that act at the pretesticular level tend to be hormonal in nature (Table 42-11).
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Written and revised by
Gerald Hurowitz, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
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