Drug info
Trimetrexate (Injection)
Gerald Hurowitz, M.D.Published 7 January 20053 min read
Key points
- Treats an infection called Pneumocystis carinii pneumonia (also called PCP).
- You should not receive this medicine if you have had an allergic reaction to trimetrexate, leucovorin, or methotrexate (Rheumatrexreg;), or if you are pregnant.
- Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Trimetrexate (Injection)
Trimetrexate (tri-me-TREX-ate)
Treats an infection called Pneumocystis carinii pneumonia (also called PCP).
Brand Name(s):
NeuTrexin
There may be other brand names for this medicine.
When This Medicine Should Not Be Used:
You should not receive this medicine if you have had an allergic reaction to trimetrexate, leucovorin, or methotrexate (Rheumatrexreg;), or if you are pregnant.
How to Use This Medicine:
Injectable
- This medicine is very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. It may also be given by a home health caregiver.
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
- You will be given a second drug called leucovorin (Wellcovorinreg;) on the same days that you receive trimetrexate. You also need to be given leucovorin for 3 days after your last dose of trimetrexate. Leucovorin helps prevent some very serious side effects of trimetrexate, including possible death. Follow all of your doctor's instructions about both medicines.
If a dose is missed:
- This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.
How to Store and Dispose of This Medicine:
- If you store this medicine at home, keep it at room temperature, away from heat, moisture, and direct light. After the powder medicine has been mixed with the liquid, you should use it right away. If you must store the mixture in the refrigerator, store it only up to 24 hours. Do not freeze.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover or outdated medicine and used IV bags, vials, or tubing.
- Keep all medicine away from children and never share your medicine with anyone.
Written and revised by
Gerald Hurowitz, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.
