Listening to classical music modulates genes that are responsible for brain functions

Although listening to music is common in all societies, the biological determinants of listening to music are largely unknown. According to a latest study, listening to classical music enhanced the activity of genes involved in dopamine secretion and transport, synaptic neurotransmission, learning and memory, and down-regulated the genes mediating neurodegeneration. Several of the up-regulated genes were known to be responsible for song learning and singing in songbirds, suggesting a common evolutionary background of sound perception across species.

Listening to music represents a complex cognitive function of the human brain, which is known to induce several neuronal and physiological changes. However, the molecular background underlying the effects of listening to music is largely unknown. A Finnish study group has investigated how listening to classical music affected the gene expression profiles of both musically experienced and inexperienced participants. All the participants listened to W.A. Mozart's violin concert Nr 3, G-major, K.216 that lasts 20 minutes.

Listening to music enhanced the activity of genes involved in dopamine secretion and transport, synaptic function, learning and memory. One of the most up-regulated genes, synuclein-alpha (SNCA) is a known risk gene for Parkinson's disease that is located in the strongest linkage region of musical aptitude. SNCA is also known to contribute to song learning in songbirds.

"The up-regulation of several genes that are known to be responsible for song learning and singing in songbirds suggest a shared evolutionary background of sound perception between vocalizing birds and humans", says Dr. Irma Järvelä, the leader of the study.

In contrast, listening to music down-regulated genes that are associated with neurodegeneration, referring to a neuroprotective role of music.

"The effect was only detectable in musically experienced participants, suggesting the importance of familiarity and experience in mediating music-induced effects", researchers remark.

Classical music, whether you love it or hate it, has been a powerful cultural force for centuries. While it no longer dominates the music scene, the argument for continued appreciation of the genre goes far beyond pure aural aesthetics. Classical music has been lauded for its ability to do everything from improve intelligence to reduce stress, and despite some exaggeration of its benefits, science shows us that it actually does have a marked effect on the brain in a number of positive ways.

Emotional expression in music and speech affect the brain similarly.

Music is a very strong form of emotional communication across all cultures, but why? Research may have the answer. Studies show that music, including classical arrangements, has the ability to send chills down your spine or make your heart swell with joy through its use of different musical modes. For example, in Western music, the major mode is associated with excited, happy emotions, the minor with sad emotions. Similar results were found in other cultures around the world despite differences in the emotions that these cultures associate with the varying modes. The reason these musical modes have the ability to convey so much emotion is because they imitate the tonal characteristics of emotion in the voice, tapping into our innate communicative abilities and our cultural associations alike.