Metal allergies may affect joint replacement success

Metal sensitivities can lead to failure of replacement joints, and patients should be carefully evaluated for a possible reaction after the surgery, according to a new review of past research.

“We think patients and doctors should be aware of hypersensitivity or allergy reactions to implanted joints and to monitor for signs and symptoms,” said Dr. Michelle L. Pinson, one of the authors of the new paper.

“However, a hypersensitivity reaction to a hip or knee replacement is not that common, when you look at all the patients who have had successful and stable joint replacements,” added Pinson, of Wilford Hall Ambulatory Surgical Center in San Antonio, Texas.

The number of total joint replacements in the U.S. is on the rise, and so is the number of revisions, according to the authors.

Earlier replacement joints were all-metal and prone to shedding as the parts rubbed against each other and surrounding tissue.

Cobalt, chromium, molybdenum, tungsten, manganese, titanium, aluminum, vanadium and nickel are all common metals used in joint replacements.

According to an unrelated 2010 study in Chemical Research in Toxicology, up to 17% of women and 3% of men are allergic to nickel.

“For some patients, an allergic reaction to metal in a joint can be very serious, however many reactions are mild and not too serious,” Pinson said.

There is no consensus on how to treat that kind of joint failure, they note, but for minor cases pain may be managed with medications, physical therapy or steroid injections.

If the joint swells or loosens, it may need to be replaced with different components, for example non-nickel components if that’s what causing the trouble.

Pinson and her colleagues included randomized controlled trials, case studies, observational studies and previous reviews in their analysis, which was published online June 13 in the Annals of Allergy, Asthma & Immunology.

Among their conclusions is that it’s still not clear whether metal joints increase sensitivity to metal, or if existing metal sensitivity leads to more joint failure after implantation.

Patients who experience new joint pain, rash or hives that don’t respond to usual treatment within several weeks to a few years after joint replacement should be considered for an allergy patch test, Pinson said.

Most researchers suggest that patients with a history of metal sensitivity should be tested before undergoing surgery, she said.

“In general, hypersensitivity testing results may guide surgeons to consider implants with no or minimal amounts of the metals to which the patient positively reacted, especially in the case of joint implant revisions,” she said.

Even so, it’s still not entirely clear what a positive result on a skin or blood metal allergy test means, according to Dr. Jared R.H. Foran of Golden, Colorado, who was not part of the new study.