Pulmonary Heart Disease (Cor Pulmonale)

Introduction

Essentials of Diagnosis

• Symptoms and signs of chronic bronchitis and pulmonary emphysema.
  
• Elevated jugular venous pressure, parasternal lift, edema, hepatomegaly, ascites.
  
• ECG shows tall, peaked P waves (P pulmonale), right axis deviation, and right ventricular hypertrophy.
  
• Chest x-ray: Enlarged right ventricle and pulmonary artery.
  
• Echocardiogram or radionuclide angiography excludes primary left ventricular dysfunction.

General Considerations

The term "cor pulmonale" denotes right ventricular hypertrophy and eventual failure resulting from pulmonary disease and attendant hypoxia or from pulmonary vascular disease. Its clinical features depend upon both the primary underlying disease and its effects on the heart.

Cor pulmonale is most commonly caused by COPD. Less frequent causes include pneumoconiosis, pulmonary fibrosis, kyphoscoliosis, primary pulmonary hypertension, repeated episodes of subclinical or clinical pulmonary embolization, Pickwickian syndrome, schistosomiasis, and obliterative pulmonary capillary or lymphangitic infiltration from metastatic carcinoma.

Clinical Findings

A. Symptoms and Signs
The predominant symptoms of compensated cor pulmonale are related to the pulmonary disorder and include chronic productive cough, exertional dyspnea, wheezing respirations, easy fatigability, and weakness. When the pulmonary disease causes right ventricular failure, these symptoms may be intensified. Dependent edema and right upper quadrant pain may also appear. The signs of cor pulmonale include cyanosis, clubbing, distended neck veins, right ventricular heave or gallop (or both), prominent lower sternal or epigastric pulsations, an enlarged and tender liver, and dependent edema.

B. Laboratory Findings
Polycythemia is often present in cor pulmonale secondary to COPD. The arterial oxygen saturation is often below 85%; PCO2 may or may not be elevated.

C. Electrocardiography and Chest X-Ray
The ECG may show right axis deviation and peaked P waves. Deep S waves are present in lead V6. Right axis deviation and low voltage may be noted in patients with pulmonary emphysema. Frank right ventricular hypertrophy is uncommon except in primary pulmonary hypertension. The ECG often mimics myocardial infarction; Q waves may be present in leads II, III, and aVF because of the vertically placed heart, but they are rarely deep or wide, as in inferior myocardial infarction. Supraventricular arrhythmias are frequent and nonspecific.