The Deadly Link Between Heart Disease and Alzheimer’s

If the threat of a heart attack is not enough to compel Americans to trade in their cheeseburgers and recliners for salmon and exercise bikes, how about mounting evidence that cardiovascular disease may greatly increase one’s risk of developing mind-destroying Alzheimer’s disease?

As scientists delve further into the twin pathologies of cardiovascular disease and dementia, they are increasingly convinced that afflictions of the heart and brain share common triggers and biochemical characteristics, including inflammation, oxidative stress, and hypoxia, an oxygen deficit caused by impaired blood flow.

Fortunately, many nutritional and botanical agents that have shown great efficacy in preventing and treating cardiovascular disease also appear to work via several important mechanisms to preserve healthy cognitive function and ward off the crippling effects of Alzheimer’s and other forms of senile dementia.

In this article, we examine the growing evidence indicating that cardiovascular disease may greatly increase one’s likelihood of developing Alzheimer’s, as well as strategies you can adopt today to safeguard the health of your heart and your mind.

Twin Afflictions of Heart Disease and Alzheimer's

The latest data show that more than 60 million Americans suffer from some form of heart disease, including coronary artery disease, congestive heart failure, and cardiac arrhythmias (abnormal rhythms of the heart). Coronary artery disease in particular affects more than 13 million Americans.1 Although heart disease traditionally has been thought of as a "man's disease," nearly half of the 600,000 Americans who will die from heart disease this year are women. With its alarming growth rate and lack of a cure, Alzheimer's disease is poised to become one of the most insidious medical problems of the twenty-first century. This devastating neurological condition progressively destroys one's memory and ability to think. Alzheimer's now affects more than 5 million Americans, including one of eight Americans aged 65 or older and nearly half of those over the age of 85. Someone in the United States develops Alzheimer's every 72 seconds, and according to current projections, by 2050 a new case of Alzheimer's disease will emerge every 33 seconds.

Alzheimer's Destroys Memory in Multiple Ways

While scientists have not yet been able to pinpoint the exact cause of Alzheimer's, they have been able to elucidate some of the biochemical processes that produce the hallmark mental changes characteristic of the disease. First, Alzheimer's involves a significant decline in brain levels of acetylcholine, a neurochemical that is vitally important for memory formation and retention. Second, the disease is accompanied by an accumulation of harmful amyloid-beta deposits, or senile plaques, in the brain. Third, brain autopsies of Alzheimer's patients show evidence of substantial oxidative damage wrought by free radicals. When energy is generated, free radicals are produced in every cell in the body, particularly brain cells; however, in Alzheimer's disease, free radicals are produced in much greater amounts then normal, leading to significant damage to the brain. In a recent article on this topic in the Annals of the New York Academy of Sciences, the investigators concluded that "altogether, our findings emphasize the importance of . . . oxidative stress in the pathogenesis of [Alzheimer's disease]."