Ulcer - peptic
Key points
- Ulcers are erosions in the lining of the stomach or duodenum (the first part of the small intestines).
- Normally, the lining of the stomach and small intestines have protection against the irritating acids produced in your stomach.
- It may awaken you at night, occur 2-3 hours after you eat, or get worse if you skip a meal.
- During an EGD, the doctor may take a biopsy from the wall of the intestines to test for H. pylori.
Alternative names
Peptic ulcer; Ulcer - duodenal or gastric; Duodenal ulcer
Definition
Ulcers are erosions in the lining of the stomach or duodenum (the first part of the small intestines). An ulcer in the stomach is called a gastric ulcer. An ulcer in the duodenum is called a duodenal ulcer. Together, ulcers of the stomach and duodenum are referred to as peptic ulcers.
Most ulcers are erosions of the first layer of the inner lining. If the hole goes all the way through, this is called a perforation of the intestinal lining. This can cause shock and is a medical emergency.
Causes, incidence, and risk factors
Normally, the lining of the stomach and small intestines have protection against the irritating acids produced in your stomach. For a variety of reasons, the protective mechanisms may become faulty, leading to a breakdown of the lining. This results in inflammation (gastritis) or an ulcer.
The most common cause of such damage is a bacterium called Helicobacter pylori. Most people with peptic ulcers have this organism living in their gastrointestinal (GI) tract. On the other hand, many people have this organism living in their GI tract but they don't get an ulcer.
OTHER FACTORS can make it more likely for you to get an ulcer, including:
- Using aspirin, ibuprofen, or naproxen
- Drinking alcohol excessively
- Smoking cigarettes and using tobacco
In addition, if you have a family history of ulcers or you are blood type 0, you are more likely to get a duodenal ulcer. There is also a rare condition called Zolliger-Ellison syndrome in which a tumor in the pancreas secretes a substance that causes ulcers throughout the stomach and duodenum.
A once popular belief was that stress causes ulcers. This is not true. Stress may make you experience more pain from an ulcer and it may make it more difficult to heal from an ulcer. But, stress does not cause an ulcer.
Symptoms
Abdominal pain is the main symptom. It may awaken you at night, occur 2-3 hours after you eat, or get worse if you skip a meal. The pain may be relieved by antacids or milk.
Other possible symptoms include:
- Nausea, vomiting
- Weight loss
- Fatigue
- Heartburn, indigestion, belching
- Chest pain
- Vomiting blood
Written and revised by
David Cohen, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.