Conn's syndrome
Key points
- Primary hyperaldosteronism is a syndrome associated with increased secretion of the hormone aldosterone (see the aldosterone test) by the adrenal gland, caused by an abnormality within the gland.
- Primary hyperaldosteronism used to be considered a rare condition, but some experts believe that it may be the cause of high blood pressure in 0.5% to 14% of patients.
- Primary hyperaldosteronism resulting from an adenoma (tumor) is usually treated surgically.
- The prognosis for primary hyperaldosteronism is good with early diagnosis and treatment.
Alternative names
Hyperaldosteronism - primary and secondary
Definition
Primary hyperaldosteronism is a syndrome associated with increased secretion of the hormone aldosterone (see the aldosterone test) by the adrenal gland, caused by an abnormality within the gland.
In secondary hyperaldosteronism, the increased production of aldosterone by the adrenal cortex is caused by something outside the adrenal gland that mimics the primary condition.
Causes, incidence, and risk factors
Primary hyperaldosteronism used to be considered a rare condition, but some experts believe that it may be the cause of high blood pressure in 0.5% to 14% of patients. Most cases of primary hyperaldosteronism result from a benign tumor of the adrenal gland and occur in people between 30 and 50 years old.
The excess aldosterone secreted in this condition increases sodium reabsorption and potassium loss by the kidneys and results in electrolyte imbalances.
Secondary hyperaldosteronism is generally related to hypertension (high blood pressure) and swelling disorders, such as cardiac failure, cirrhosis of the liver, and nephrotic (kidney) syndrome. In these disorders, various mechanisms from the individual disease process cause the level of the hormone to be elevated.
Symptoms
- High blood pressure
- Headache
- Muscle weakness
- Fatigue
- Intermittent paralysis
- Numbness
Signs and tests
- Low serum potassium level
- Abdominal CT scan that shows adrenal mass
- Elevated plasma aldosterone level
- Elevated urinary aldosterone
- Low plasma renin activity
- ECG that shows abnormalities associated with low potassium levels
This disease may also alter the results of the following tests:
- Urine sodium
- Serum sodium
- Urine potassium
- Serum magnesium test
- CO2
Treatment
Primary hyperaldosteronism resulting from an adenoma (tumor) is usually treated surgically. Removal of adrenal tumors may control the symptoms. Even after surgery, some people have elevated blood pressure and require medication.
Written and revised by
David Cohen, M.D.
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