Placebo as good as most drugs for kids' migraines

Key points
- A drug-free placebo pill prevents migraines in kids and teens just as well as most headache medicines, according to a new review of past evidence.
- In the new analysis, published Monday in JAMA Pediatrics, placebo pills alone led to a drop in kids' headache frequency from between five and six headaches per month to three per month.
- Conclusions High placebo response rates are consistent across all trials and may represent the principal challenge in pediatric trials of drugs for abortive treatment of migraine.
- Researchers found only two drugs known to help migraine-plagued adults reduced the frequency of kids' headaches better than a placebo.
A drug-free placebo pill prevents migraines in kids and teens just as well as most headache medicines, according to a new review of past evidence.
Researchers found only two drugs known to help migraine-plagued adults reduced the frequency of kids' headaches better than a placebo. And even in those cases, the effect was small - a difference of less than one headache per month compared to the dummy pills.
"Parents should be aware that our medication choices aren't as good as they should be," said Dr. Jennifer Bickel, a neurologist and headache specialist at Children's Mercy Hospitals and Clinics in Kansas City, Missouri.
Bickel, who wasn't involved in the new research, said no drugs have been rigorously tested and approved for preventing migraines in kids, so doctors have to rely on headache drugs made for adults.
Those medicines, she added, are "not a miracle cure."
For cases when medication may not be enough, Bickel told Reuters Health, parents may want to look into relaxation techniques - such as meditation - for kids with chronic headaches.
According to data from the Cleveland Clinic, about 2 percent of young children and 7 to 10 percent of older kids and teenagers up to age 15 get migraines.
Placebo Effect: Fake Pill, Real Power To understand how a person can be so desperate for pain relief that they can trick themselves into thinking they've been given an agony-abating medication, it helps to step back in history: In 1772, when smallpox and typhoid fever left thousands of patients in misery (and today's narcotics were a mere fantasy), Scottish physician William Cullen had two seemingly bizarre ideas. The first was that sympathy could cure disease. The second was that an inert substance, like mint water, could relieve pain. Turns out, he was onto something, and his notes mark the birth of the placebo effect, or what happens when an inactive treatment convinces your brain that it's a powerful cure.
Centuries later, the phenomenon was hinted at in pop culture in the 1939 movie The Wizard of Oz (although the guy was a faker, his mind tricks still helped the movie's characters feel better), but it really hit the big time in 1955, when war surgeon Henry Beecher published an article that claimed more than one-third of all patients could be cured by placebos alone. His paper caused a bigger stir then than a Kardashian wedding does today and solidified the placebo effect as scientific fact.
Yet placebo is still sometimes considered a dirty word. Pharma companies go to expensive lengths to show that their meds outperform inert pills, and drug trials are often dismissed for having "just a placebo effect." For a consumer, though, the most fascinating thing about faux treatments (yes, including stuff like Cullen's mint water) is what they reveal about the healing power of the mind.
Written and revised by
Gerald Hurowitz, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.
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