Health panel cautious on HPV screening vs Pap

A U.S. government-backed medical panel on Wednesday took a cautious view of a new generation of cervical cancer tests, discouraging women under the age of 30 to screen for human papillomavirus as a way to prevent cancer.

In proposing changes to its 2003 guidelines on cervical cancer, the U.S. Preventive Services Task Force (USPSTF) said it still didn't have enough evidence to weight the health benefits and harms of HPV testing in women older than 30.

Overall, the panel maintained that a Pap smear test in women between 21 and 65 years of age "substantially" reduces the number of cervical cancer cases and deaths.

The panel, comprised of primary care physicians who are experts at evidence-based research, is highly influential in setting the tone for primary care practice.

It must weigh the potential benefits of early detection of disease through screenings against the potential harms to healthy patients who may be subjected unnecessarily to more invasive procedures or side-effects.

Earlier this month, the task force came under fire from doctors and cancer patients after recommending against prostate cancer screening in healthy men.

It was the subject of a similar controversy in 2009 after recommending that doctors scale back on routine mammograms in women in their 40s and 50s to prevent breast cancer.

Under President Barack Obama's healthcare overhaul, the services recommended by USPSTF would also have to be covered by insurance companies with no co-pays or deductibles.

On Wednesday, the task force largely aligned with general practice and cancer societies' guidelines on screening for cervical cancer it terms of frequency and age group-specific recommendations.

Maintaining the recommendation of screening women every three years, the panel said it found "little to no benefit" in screening women older than 65 who had been previously tested and no impact on women younger than 21.

Previously, USPSTF's recommendations applied to women of 21 years old or within three years of becoming sexually active.

FALSE POSITIVES

However, USPSTF was more skeptical of HPV testing and so-called "liquid-based" Pap tests, which have largely replaced the conventional Pap smear in the United States.

After reviewing all clinical data available on the subject, the panel recommended against HPV tests, alone or in combination with a Pap, in women under 30, noting that screening for HPV causes more false positive cancer results than the Pap smear alone.

"There are no clinically important differences between liquid-based and conventional cytology" in cervical cancer detection, the task force said. For women over 30, evidence remains insufficient to weigh HPV test harms and benefits.