Botox May Ease Enlarged Prostate Symptoms

Botox, which has already proven its worth banishing wrinkles and battling migraines, is now emerging as a possible treatment for prostate problems.

Researchers from the University of Pittsburgh Medical Center say Botox may help alleviate symptoms of an enlarged prostate - a condition called benign prostatic hyperplasia (BPH). They presented their findings May 11 at the American Urological Association meeting in San Francisco.

At another presentation at the same meeting, researchers reported that higher levels of so-called "free" testosterone were associated with an increased risk of prostate cancer.

The University of Pittsburgh scientists injected Botox into the prostates of 11 men between the ages of 50 and 82. All had an enlarged prostate, which causes symptoms such as frequent urination, an inability to completely empty the bladder and urinary tract infections.

The men had all tried alpha-blocker treatments, and had not responded to the therapy.

Within three to seven days of the injections, the men''s average score on a prostate symptom scale had decreased by 62 percent, and a quality-of-life scale score increased by 57 percent.

"We have completed a number of studies that have shown Botox injections are a safe and effective treatment for conditions of the lower urinary tract," Dr. Michael Chancellor, a professor of urology and gynecology, said in a statement. "In this study, we have shown the same may be true for using Botox injections for enlarged prostate."

In the testosterone study, researchers found higher levels were associated with an increased risk of prostate cancer.

One of the study authors, Dr. J. Kellogg Parsons, said the researchers wanted to see if higher levels of testosterone were linked to a higher incidence of prostate cancer because testosterone-replacement therapy is becoming more widespread.

"In this cohort of aging men, we did see a significant association between the serum testosterone index and prostate cancer," said Parsons, an instructor of urology at Johns Hopkins School of Medicine.

He said that men whose testosterone levels placed them in the upper 75th percentile had an 88 percent higher risk of prostate cancer than men in the 25th percentile. Men in the lowest 25th percentile, he added, had levels of free testosterone considered clinically low.

Each year, more than 230,000 men are diagnosed with prostate cancer, according to the American Cancer Society (ACS). Over a lifetime, prostate cancer strikes one of every six men, according to the ACS. Almost 30,000 American men die annually from the disease.

In its early stages, prostate cancer often has no symptoms. As it advances, it can cause impotence, blood in the urine and pelvic or hip pain.

For the testosterone study, Parsons and his colleagues tested blood samples from 794 middle-aged and older men, including 114 who had prostate cancer. The samples had been collected over a 40-year period as part of another study. The average age of diagnosis for the men with prostate cancer was 75.