Breast Cancer Prevention Drug Shown to Decrease Bone Density and Structure in Postmenopausal Women

Exemestane, a drug used in the prevention of breast cancer in postmenopausal women, has a negative effect on bone density and structure in these women, despite calcium and vitamin D supplements.

This first-ever study examined the effect of this drug on women’s bone health and found that on three major outcome measures, taking exemestane for two years worsens age-related bone loss in postmenopausal women. The results are in an article entitled, “Bone Density and Structure in Healthy Postmenopausal Women treated with Exemestane for the Primary Prevention of Breast Cancer: a nested substudy of the MAP.3 trial”, published Online First in The Lancet Oncology.

“The study is important because of the potential for wide-spread use of this medication by women at increased risk of developing breast cancer,” said Dr. Lianne Tile, one of the authors of the study, Medical Director of the Osteoporosis Clinic and Staff General Internist at University Health Network (UHN).

The first author is Dr. Angela Cheung, Director of the Centre of Excellence in Skeletal Health Assessment and the Osteoporosis Program, holder of the Lillian Love Chair in Women’s Health at the UHN, Staff, General Internal Medicine and Endocrinology. Other authors at UHN include: Dr. Savannah Cardew, Dr. George Tomlinson, Dr. Moira Kapral, Dr. Christine Elser, Dr. Marta Erlandson, Judy Scher, Hanxian Hu, and Alice Demaras.

In addition, Dr. David McCready, Dr. Ruth Heisey, Irene Ho, Suzanne Cohen, Alexandra Tse, Queenie Wong, Gail Jefferson, Diana Yau and Karen Stratton at UHN also contributed to the study.

This study was a nested safety substudy of the MAP.3 trial of exemestane for the primary prevention of breast cancer. The drug is a member of the class of drugs known as aromatase inhibitors. It works by decreasing the amount of estrogen circulating in the body. This can slow or stop the growth of some breast tumors that need estrogen to grow. Studies have shown that treating women at high-risk of developing breast cancer with this drug can cut their risk of developing the disease by two-thirds.

In the substudy, 351 postmenopausal women, with a median age of 61.3, from five North American centres, including Toronto General Hospital, Mount Sinai Hospital and Women’s College Hospital in Toronto, participated in a two-year follow-up with the drug. These women were not osteoporotic, not on bone medications, and were supplemented to a total daily intake of 1200-1500mg calcium and 800IU vitamin D. All had baseline lumbar spine, total hip and femoral neck T-scores above -2.0. T-scores indicate how much your bone mass compares to the average bone mass of a healthy adult. A T-score of less than or equal to -2.5 indicates osteoporosis.
Osteoporosis is a condition that causes bones to become weaker, thereby increasing the risk of fracture or breakage. The most common sites of osteoporotic fracture are the wrist, spine and hip.