Chronic stress during pregnancy prevents brain benefits of motherhood, study shows

A new study in animals shows that chronic stress during pregnancy prevents brain benefits of motherhood, a finding that researchers suggest could increase understanding of postpartum depression.

Rat mothers showed an increase in brain cell connections in regions associated with learning, memory and mood. In contrast, the brains of mother rats that were stressed twice a day throughout pregnancy did not show this increase.

The researchers were specifically interested in dendritic spines – hair-like growths on brain cells that are used to exchange information with other neurons.

Previous animal studies conducted by lead author Benedetta Leuner of Ohio State University showed that an increase of dendritic spines in new mothers' brains was associated with improved cognitive function on a task that requires behavioral flexibility – in essence, enabling more effective multitasking. The dendritic spines increased by about 20 percent in these brain regions in new mothers, according to her findings.

The stress in this new study negated those brain benefits of motherhood, causing the stressed rats' brains to match brain characteristics of animals that had no reproductive or maternal experience.

The stressed rats also had less physical interaction with their babies than did unstressed rats, a behavior observed in human mothers who experience postpartum depression.

"Animal mothers in our research that are unstressed show an increase in the number of connections between neurons. Stressed mothers don't," said Leuner, assistant professor of psychology and neuroscience at Ohio State. "We think that makes the stressed mothers more vulnerable. They don't have the capacity for brain plasticity that the unstressed mothers do, and somehow that's contributing to their susceptibility to depression."

Leuner described the research during a talk Saturday (10/13) in New Orleans at Neuroscience 2012, the annual meeting of the Society for Neuroscience.

Previous research has suggested that there are a number of risk factors for postpartum depression, including hormone fluctuations, prior history of mental illness and environmental factors such as smoking or low socioeconomic status. One of the strongest predictors, however, is chronic stress during pregnancy, so Leuner sought to create an animal model that could help explain brain changes linked to postpartum depression.

"It's devastating not only for the mother, because it affects her well-being, but previous research also has shown that children of depressed mothers have impaired cognitive and social development, may have impaired physical development, and are more likely as adults to have depression or anxiety," she said. "A better understanding of postpartum depression is important to help the mother but also to prevent some of the damaging effects that this disorder can have on the child."