What are the symptoms of a serious clinical depression?

Key points
- A Major Depression is marked by a combination of symptoms that occur together, and last for at least two weeks without significant improvement.
- This list is a guide to help you understand depression.
- Symptoms from at least five of the following categories must be present for a major depression, although even a few of the symptom clusters are indicators of a depression, but perhaps not a major depression.
- If you have some of these symptoms, don't focus on how many symptoms you have.
A Major Depression is marked by a combination of symptoms that occur together, and last for at least two weeks without significant improvement. Symptoms from at least five of the following categories must be present for a major depression, although even a few of the symptom clusters are indicators of a depression, but perhaps not a major depression.
- Persistent depressed, sad, anxious, or empty mood
- Feeling worthless, helpless, or experiencing excessive or inappropriate guilt
- Hopeless about the future, excessive pessimistic feelings
- Loss of interest and pleasure in your usual activities
- Decreased energy and chronic fatigue
- Loss of memory, difficulty making decisions or concentrating
- Irritability or restlessness or agitation
- Sleep disturbances, either difficulty sleeping, or sleeping too much
- Loss of appetite and interest in food, or overeating, with weight gain
- Recurring thoughts of death, or suicidal thoughts or actions
This list is a guide to help you understand depression. It is not offered for you to diagnose yourself. If you have some of these symptoms, don't focus on how many symptoms you have. Instead, talk to a psychologist about how you have been feeling, to see if he/she can help.
Written and revised by
Andrey Nailor, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.
Explore health topics
More in this topic
Mental Health →
NewsDepression Can be a More Serious Matter for Men than Women
Depression is sometimes called the common cold of mental health, but it's unlike the common cold in at least two important respects: It doesn't go away in a week without treatment, and it doesn't affect men and women…
25 October 2006
NewsDepression symptoms less likely in kids with accurate self-perceptions
Children who can accurately assess how their classmates feel about them - even if those feelings are negative - are less likely to show symptoms of depression, according to Florida State University researchers.…
24 October 2006
NewsBMI can be an intermediate variable linking depression and hypertension symptoms
BMI can be an intermediate variable linking symptoms of depression and hypertension. "There is growing evidence that symptoms of depression influence the development of cardiovascular disease. The objective of this…







