Vanderbilt study shows exercise can curb marijuana use and cravings

Vanderbilt researchers are studying heavy users of marijuana to help understand what exercise does for the brain, contributing to a field of research that uses exercise as a modality for prevention and treatment.

Participants saw a significant decrease in their cravings and daily use after just a few sessions of running on the treadmill, according to a Vanderbilt study published today in the journal PLoS ONE. It is the first study to demonstrate that exercise can reduce cannabis use in persons who don't want to stop.

Twelve study participants - eight female and four male - were selected because they met the criteria for being 'cannabis-dependent' and did not want treatment to help them stop smoking pot.

During the study their craving for and use of cannabis was cut by more than 50 percent after exercising on a treadmill for 10 30-minute sessions over a two-week period.

“This is 10 sessions but it actually went down after the first five. The maximum reduction was already there within the first week,” said co-author Peter Martin, M.D., director of the Vanderbilt Addiction Center.

“There is no way currently to treat cannabis dependence with medication, so this is big considering the magnitude of the cannabis problem in the U.S. And this is the first time it has ever been demonstrated that exercise can reduce cannabis use in people who don't want to stop.”

Mac Buchowski, Ph.D., director of the Vanderbilt Energy and Balance Laboratory

Cannabis abuse or dependence and complications have increased in all age groups in the past decade in the United States.

In 2009, approximately 16.7 million Americans age 12 or older reported cannabis use in the previous month and 6.1 million used the drug on 20 or more days per month, the authors wrote.

Peter Martin, M.D., director, Vanderbilt Addiction Center

Treatment admissions for cannabis dependence have risen from 7 percent of total addiction treatment admissions in 1998 to 16 percent by 2009.

Co-author Mac Buchowski, Ph.D., director of the Vanderbilt Energy Balance Laboratory, said the importance of this study and future studies will only continue to grow with the new knowledge of the role of physical activity in health and disease.

“It opens up exercise as a modality in prevention and treatment of, at least, marijuana abuse. And it becomes a huge issue with medical marijuana now available in some states,” he said. “What looks like an innocent, recreational habit could become a disease that has to be treated.”

Martin sees the study results as the beginning of an important area of research to better understand brain mechanisms of exercise in addiction.