Despite the risks, mephedrone users in the UK are ready to try the next legal high

Since mephedrone was made illegal in the UK in 2010, the street price of the drug has risen while the quality has degraded, which in turn may have reduced use of the drug. New research published online today reveals that young people who continued to use mephedrone after it became illegal would switch to a new legal high if it were pure and rated highly by their friends or on the Internet. They would be less deterred by a lack of scientific research on the new drug.

Mephedrone is a synthetic stimulant - a 'designer drug' - that became widely used in the UK from 2008 to 2010. Its rise in popularity may have been caused by its legality and ready availability (typically sold online as 'plant food'), and also to the reduced purity of street cocaine and ecstasy during the same period. In 2010, because of its similarity to amphetamines and frenzied media reporting of the harmful effects of the drug, mephedrone was made illegal in the UK and scheduled as a Class B drug. The drug is still available through street dealers and online.

Research published online today in the journal Addiction shows that after taking mephedrone, users showed impaired working memory as well as the typical stimulant drug effects of euphoria, self confidence and buzzing.

While intoxicated, they also experienced marked craving for mephedrone and typically binged on the drug, taking it repeatedly for an average of eight hours. When drug-free, this group showed higher levels of depression and poorer long term memory compared to controls using drugs other than mephedrone.

When asked what factors might influence them to try a new legal high, the same users said they would be drawn to a new drug that was pure and had few short-term or long-term harms. While they would be attracted by positive reports from friends and on the Internet, lack of scientific research on the drug and its legal status were less important factors.

Mephedrone, also called 4-methylmethcathinone (4-MMC), or 4-methylephedrone is a synthetic stimulant. A stimulant is a psychoactive drug which induces temporary improvements in mental and/or physical function. Mephedrone is an entactogen drug - a class of psychoactive drugs that produce distinctive emotional and social effects, similar to those of Ecstasy (MDMA).

STREET NAMES

Mieow, Meow, Meph, Mephedrone, MCAT, 4MMC

The status of the legality of the popular laboratory-produced drug is no longer in debate: it is illegal to sell or possess. By no means is the subject moot, however, as lobbyists and researchers continue to pursue legal means to extract and apply the active ingredients of the Khat plant. Conservative citizens and left-wing demonstrators will continue to dispute the U.K.’s decision although the fact that the U.S. has already banned the drug will only offer weight to the right’s argument. Some conventional wisdom has it that to ban everything that comes along without justification, scientific or moral, is impulsive and possibly counter-productive to the furtherance of medical research and forward-directed thought.