Blood Test for Teen Depression Under Study

Scientists have developed a blood test that may help diagnose major depression in teens and young adults.

The test is in very early stages. However, scientists hope it will someday make diagnosing depression more objective for teens.

"The bottom line is that a test is possible from blood that can differentiate teens with major depression from those who do not have it," says scientist Eva Redei, PhD, professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine.

The findings are published in Translational Psychiatry.

It's crucial to point out that the study is very preliminary and not ready for clinical use, says Alexander B. Niculescu III, MD, PhD, associate professor of psychiatry and medical neuroscience at Indiana University School of Medicine. He is also researching blood tests for depression and other mood disorders.

Teens and Depression

Major depression affects about 1% of children under age 12, Redei says.

By late teens and young adulthood, that figure rises to about 25%. If it is untreated in teens, their risk of substance abuse, suicide, physical illness, and other problems goes up, Redei says.

Almost 15 million Americans suffer from clinical depression, according to the National Institute of Mental Health. Depression is also the leading cause of disability among 15- to 44-year-olds. Still, even though depression is so common, there are many misconceptions about its symptoms, causes and treatment. The problem is that misinformation gives rise to stigma and isolation. Individuals with clinical depression often feel alone because others expect them to simply snap out of it or stop being lazy. These kinds of myths can make people not want to seek treatment. Untreated depression also can have devastating consequences like health complications, drug or alcohol abuse and suicide. Here’s a selection of myths you might not know about.

Doctors diagnose depression by asking about symptoms. These can include feeling sad or blue for an extended period of time, withdrawing from activities or friends, and suddenly doing poorly at school. When teens talk to a doctor, they may not communicate well, Redei says. "This is the generation, the age group that needs the most help," Redei tells WebMD.

Blood Test for Depression

Redei's team focused on 26 blood biomarkers, or indicators, for depression and anxiety. These indicators reflect the activity of genes related to depression.

Depression Myths and Facts Demystified

Depression is deep sadness. Depression goes beyond the blues or profound sadness. A depressed mood is just one symptom of depression. While depression varies from person to person, many feel irritable, guilty, worthless and hopeless. Many lose interest in activities they used to enjoy. They become indifferent. They can isolate themselves from others. They also experience difficulty concentrating or remembering things.