Zaditor
Key points
- Zaditor is a prescription eye drop indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.
- The recommended dose is 1 drop in the affected eye(s) twice daily.
- ZADITOR ™ is a sterile ophthalmic solution containing ketotifen for topical administration to the eyes.
- Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and mast cell stabilizer.
Zaditor is a prescription eye drop indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.
Zaditor is a relatively selective, noncompetitive histamine antagonist (H1-receptor) and mast cell stabilizer. It inhibits the release of mediators from cells involved in hypersensitivity reactions. Decreased chemotaxis and activation of eosinophils has also been demonstrated.
Zaditor begins to work within minutes after administration and lasts up to 12 hours.
Dosing and Formulation
The recommended dose is 1 drop in the affected eye(s) twice daily. Patients who wear contact lenses should remove them before using Zaditor and should not reinsert them for at least 10 minutes.
Zaditor is available by prescription in 7.5 mL plastic bottles.
Pronounced: ZA-di-tor Active Ingredient: Ketotifen fumarate Brand name(s): Zaditor Strength(s): 0.025% Dosage Form(s): Ophthalmic solution Company Name: Ciba Vision, A Novartis Company Availability: Prescription only Date Approved by the FDA: July 7, 1999 Established Name: Ketotifen Fumarate Ophthalmic Solution Category:
- Antihistamine, H 1 - receptor, ophthalmic
- mast cell stabilizer, ophthalmic
- antiallergic, ophthalmic
Description
ZADITOR ™ is a sterile ophthalmic solution containing ketotifen for topical administration to the eyes.
Ketotifen fumarate is a finely crystalline powder with an empirical formula of C23H23NO5S and a molecular weight of 425.50.
Clinical pharmacology
Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and mast cell stabilizer. Ketotifen inhibits the release of mediators from cells involved in hypersensitivity reactions.
Decreased chemotaxis and activation of eosinophils has also been demonstrated.
In human conjunctival allergen challenge studies, ZADITOR ™ was significantly more effective than placebo in preventing ocular itching associated with allergic conjunctivitis. The action of ketotifen occurs rapidly with an effect seen within minutes after administration.
Possible side effects of Zaditor
(This is NOT a complete list of side effects reported with Zaditor. Your health care provider can discuss with you a more complete list of side effects.)
Written and revised by
David Cohen, M.D.
Our doctors write and review articles for accuracy and keep them up to date.
health.am provides general information, not medical advice. Always consult a qualified health professional about your own health.
Explore health topics
More in this topic
Lungs, Asthma & Allergies →
NewsInfant gut bacteria and food sensitization: Associations in the first year of life
A new study from Canadian researchers at the University of Alberta and University of Manitoba is shedding new light on changes in intestinal bacteria of infants that can predict future development of food allergies or…
4 March 2015
NewsMarijuana: The allergen you never knew existed
Growing up, you may have been given reasons for not smoking marijuana. What you may not have heard is that marijuana, like other pollen-bearing plants, is an allergen which can cause allergic responses. A new article…
3 March 2015
NewsPregnant women with asthma need to curb urge to ask for antibiotics
Getting sick when you're pregnant is especially difficult, but women whose children are at risk for developing asthma should avoid antibiotics, according to a new study. The study, published in the Annals of Allergy,…
