Scientists discover the basis of allergic reactions

The reason why many people are allergic to birch pollen has not been fully clarified yet. It is known that a specific birch pollen protein causes the immune system to overreact. What makes it an allergen has now been discovered by scientists at the Vetmeduni Vienna. The pollen protein can bind iron. Without iron load the protein becomes an allergen. Environmental factors are possibly the reason for low iron loads in plants. This could explain the increasing numbers of allergies. The research data were published in the Journal of Biological Chemistry.

Allergies in humans and animals are on the increase. An allergic reaction may cause unpleasant symptoms like hay fever, food intolerance or skin rashes. Allergic reactions may also cause acute and life-threatening symptoms, such as asthma or anaphylactic shock.
A single pollen protein is responsible for allergies

One of the most well known allergens, i.e. substances that cause allergies, is so-called “Bet v 1” from birch pollen (Betula verrucosa). The protein was first produced artificially in the laboratory 25 years ago in Vienna, and is being used as an allergen model for research throughout the world. “Bet v 1” is the principal allergen among hundreds of other proteins of birch pollen. It renders the immune system hypersensitive and leads to the formation of disease-causing antibodies known as IgE immunoglobulins in 95 percent of persons with a pollen allergy.

Birch pollen protein in its iron-loaded state is not allergenic

Until recently it was not known why harmless molecules trigger allergies at all. Scientist Franziska Roth-Walter and her colleagues from the Messerli Research Institute have now found the possible cause. The birch pollen protein “Bet v 1” is very similar to the human protein Lipocalin 2 in terms of structure; Lipocalin 2 is mainly present in the lung. Lipocalin 2 and “Bet v 1” possess so-called molecular pockets with which they can bind iron. When these pockets remain empty, the birch pollen protein becomes an allergen and is liable to cause allergic reactions in humans and animals. The protein manipulates so-called T-helper 2 cells (Th2 cells), a certain type of immune cells, towards allergy. The human protein Lipocalin 2 also performs tasks of the immune system, depending on its iron loading.
Origin of allergy investigated in the model of birch pollen

In allergic people and other mammals, Th2 cells are predominant compared to Th1 cells. Th2 cells play an important role in allergic reactions and in combating parasites. Th1 cells serve to defend the body against bacterial and viral infections. "A typical feature of allergies is the disruption of the balance between the Th1 and Th2 immune response," explains Professor Erika Jensen-Jarolim, head of the Department of Comparative Medicine at the Messerli Research Institute.