Gene helps people resist AIDS infection - study

People who carry extra copies of a particular gene seem to be less likely to become infected with the AIDS virus, researchers said on Thursday.

The findings may eventually lead to better ways to prevent and treat HIV, which has killed more than 25 million people since it was first identified in the early 1980s, said the National Institute of Allergy and Infectious Diseases, which funded the study.

The discovery may also help explain overall human immunity against infectious diseases, the researchers write in an advance report in the journal Science.

The gene, called CCL3L1, controls production of an immune system signaling chemical, or chemokine.

Normally, genetic variation means people have slight mutations or variations in a gene, or working and non-working copies - one copy inherited from the mother and one from the father. In this case, people actually have multiple copies of the entire gene, said Dr. Sunil Ahuja of the University of Texas Health Science Center in San Antonio, who led the study.

"About five percent of the human genome has got large chunks of sequence that are duplicated," Ahuja said in a telephone interview.

For CCL3L1, some people have no copies of the gene at all and some people have four, five and more. This chemokine is associated with a receptor - a cellular entryway - known as CCR5.

CCR5 is known to affect susceptibility to HIV infection and to how quickly an infected person progresses to AIDS.

STUDYING DIFFERENT ETHNIC GROUPS

For their study Ahuja and colleagues in the United States, Britain and Argentina analyzed blood samples from more than 4,300 HIV-infected and non-infected people of different ancestral origins.

They counted how many copies of the CCL3L1 gene each person had, and found big variations.

For example, HIV-negative black adults had an average of four copies of CCL3L1, while HIV-negative European-Americans averaged two copies each and uninfected Hispanic-Americans had an average of three copies.

The more copies a person had, the less likely he or she was to be infected with HIV.

And it was not the absolute number of extra copies of the gene that mattered, Ahuja's team found. Instead, it was whether a person had more copies than average for his or her ethnic group.

In general, each extra copy of the CCL3L1 offered 4 percent to 10 percent protection from the virus, Ahuja said.

About 1 percent of people of Caucasian descent have a mutation in the CCR5 gene that makes them very unlikely to acquire HIV, or to come down with AIDS once infected. That led Ahuja's team to look at chemokines that interact with CCR5.

He described infection as a battle between the virus and the body's immune system chemokines, all trying to get into immune cells called T-cells. "The virus is trying to compete with sites for chemokines," he said.