New classification system for cardiomyopathy

Mount Sinai Hospital's Cardiologists contribute to the creation of newly proposed MOGE(S) classification system for cardiomyopathy disorders, with an easy-to-use online diagnostic app for physicians

Leading cardiologists at The Mount Sinai Hospital have contributed to the development of a new classification system called MOGE(S) for cardiomyopathies, the diseases of the heart muscle which can lead to heart enlargement and heart failure.

The new cardiomyopathy classification system was published simultaneously on November 18 by the Journal of the American College of Cardiology (JACC) and Global Heart, the journal of the World Heart Federation. The Mount Sinai Hospital co-authors include: Valentin Fuster, MD, PhD, Director of Mount Sinai Heart and Physician-in-Chief at The Mount Sinai Hospital; Sean Pinney, MD, Director of the Advanced Heart Failure and Transplantation Program at The Mount Sinai Hospital and Jagat Narula, MD, PhD, Director of Cardiovascular Imaging Program at The Mount Sinai Hospital.

The document endorsed by the World Heart Federation is a result of the monumental effort of a 17-member international committee of widely acclaimed investigators (including cardiologists, geneticists, pathologists and imagers). The committee was chaired by Dr. Narula, who also led the development of the classification system.

MOGE(S) classification system and its easy-to-use online web application tool for physicians: http://moges.biomeris.com can assist in the diagnosis and management of each individual cardiomyopathy patient by helping to classify his or her following five cardiomyopathic disorder attributes including:

Morphofunctional characteristic, or observable clinical traits

Organ involvement

Genetic inheritance pattern

Etiological, or explicit genetic defect cause

Stage of heart failure (optional)

The new system uses a more comprehensive, descriptive nomenclature to explain each individual patient's cardiomyopathy using a configuration of letters as a descriptive language or code to reveal additional details instantly for the medical community to understand exactly what type of cardiomyopathy disorder and genetic mutations a patient has.

"This new MOGE(S) code for each patient will allow for clearer and greater understanding of a patient's cardiomyopathy, easier communication among physicians, and even help us develop multicenter and multinational registries for more future research into cardiomyopathies," says Dr. Jagat Narula, who also serves as Professor of Medicine and Associate Dean for Global Health, Philip J. and Harriet L. Goodhart Chair in Cardiology at Icahn School of Medicine at Mount Sinai.

"The new MOGE(S) classification system will allow us to begin diagnosing early cardiomyopathy better, where disease is not present but genetic information and advanced cardiac imaging shows evidence of increased risk of developing the condition, which will fuel clinical decision making for prevention of cardiomyopathy," adds Dr. Narula.