Study finds state wealth affects women's heart disease risk

According to new research from Brigham and Women's Hospital (BWH), a state's level of wealth or poverty is linked with levels of cardiovascular inflammation in women. Cardiovascular inflammation is a key risk factor for heart disease. This research, led by Cheryl R. Clark, MD, ScD, the director of health equity research and intervention at the Center for Community Health and Health Equity at BWH was published March 20 in the online edition of BMC Public Health.

"We have been learning that geography matters for heart disease risk," Clark said. "Our study suggests that state-level resources may contribute to early risk factors for heart disease in women."

Researchers examined each state's gross domestic product, poverty rate and level of financial inequality, and then compared those factors to biomarkers of cardiovascular inflammation in women nation-wide who took part in the Women's Health Study. They found that women who live in wealthy states have lower levels of cardiovascular inflammation than women who live in states with fewer resources. Additionally, women who live in states with higher levels of financial inequality have higher levels of cardiovascular inflammation than women in states with lower inequality.

Researchers also found that even when an individual woman's diet, weight, personal income level, exercise and smoking habits were taken into account, the wealth of their home state still significantly impacted their level of cardiovascular inflammation.

Researchers note that further research is needed to examine the reasons behind this disparity.

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This research was supported by an NIH-National Institute of Aging grant.

Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), www.brighamandwomens.org/research , BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative.

###Lori Shanksljshanks@partners.org617-534-1604Brigham and Women's Hospital