Pediatric AIDS Clinical Trials Group (PATCG) 076 Zidovudine Regimen

Time of Administration

Zidovudine Regimen

Antepartum

100 mg orally five times daily, initiated at 14 to 34 weeks and continued throughout the pregnancy.^a

Intrapartum

During labor, intravenous zidovudine in a 1-hour initial dose of 2 mg/kg, followed by a continuous infusion of 1 mg/kg/hr until delivery.^b

Neonate

Begin at 8 to 12 hours after birth, and give syrup at 2 mg/kg every 6 hours for 6 weeks.^c

^aAcceptable alternative regimens include 200 mg three times daily or 300 mg twice daily.

^bFor elective cesarean delivery, intravenous zidovudine is begun at least 3 hours prior to surgery. For premature rupture of membranes or labor with a planned operative delivery, the loading dose may be given during 30 minutes prior to surgery.

^cIntravenous dosage for infants who cannot tolerate oral intake is 1.5 mg/kg intravenously every 6 hours.

From U.S. Public Health Service, 2003.