TABLE 22-32
| TABLE 22-32. AMBULATORY TREATMENT OF HYPERTENSION | |||
| DOSE (mg/kg/day) | |||
DRUGS | INITIAL | MAXIMAL | INTERVAL BETWEEN DOSES (HOURS) |
Diuretics | |||
Chlorothiazide | 10 | 20 | 12-24 |
Hydrochlorothiazide | 0.5 | 2 | 12-24 |
Furosemide | 1 | 6 | 12-24 |
Vasodilators | |||
Hydralazine | 0.75 | 7.5 | 6-12 |
Minoxidil | 0.1 | 1 | 24 |
Central α2-adrenergic antagonists | |||
Clonidine | 0.005 | 0.025 | 12 |
α-Methyldopa | 10 | 60 | 8-12 |
β-Adrenergic blocking agents | |||
Propranolol | 1 | 8 | 8-12 |
Metoprolol | 1 | 5 | 12 |
Atenolol | 1 | 8 | 24 |
Nadolol | 0.5 | 4 | 24 |
Labetalol | 2 | 10 | 8-12 |
α-Adrenergic blocking agents | |||
Prazosin | 0.02 | 0.4 | 8-12 |
Phentolamine | 0.2a | 1.0a | |
Phenoxybenzamine | 1 | 5 | 24 |
Calcium channel blockers | |||
| Verapamil | 4 | 8 | 12-24 |
| Nifedipine (long acting) | 30b | 120b | 12-24 |
| Diltiazem | 1.5 | 3.5 | 12-24 |
| Amlodipine | 0.1 | 0.3 | 24 |
Converting enzyme inhibitors or receptor blockade | |||
| Captopril | 1 | 6 | 8-12 |
| Enalapril | 0.1 | 0.75 | 12-24 |
| Lisinopril | 0.1 | 0.75 | 24 |
| Losartan | 1 | 2 | 12-24 |
| a Given as single doses; see text. | |||
| b Total daily dose (mg). | |||