TABLE 22-31
| TABLE 22-31. SITES OF ACTION OF HYPOTENSIVE AGENTS | |
| MAIN SITE AND BASIC MECHANISM OF ACTION | DRUG |
Hypothalamus | Reserpine |
Medulla | Methyldopa, clonidine, barbiturates |
Sympathetic ganglia (blockade) | Trimethaphan camsylate (Arfonad) |
Postganglionic adrenergic nerves (depression) | Guanethidine, bethanidine, debrisoquin |
Adrenergic nerve endings (catecholamine depletion) | Reserpine |
α-Adrenergic receptors (blockade) | Phentolamine, phenoxybenzamine, prazosin labetalol |
β-Adrenergic receptors (blockade) | Propranolol, esmolol, labetalol, metoprolol |
Arteriolar smooth muscle (relaxation) | Hydralazine, minoxidil, diazoxide, diuretics, nitroprusside, angiotensin-converting enzyme inhibitor, angiotensin receptor blockade, calcium channel blockade |
Decrease in body sodium and blood volume | Thiazides, furosemide, spironolactone, triamterene |