Pharmacologic Treatment of Urge Incontinence.
| Table 45-8. Pharmacologic Treatment of Urge Incontinence. | ||||
Drug Name | Trade Name | Drug Type | Dosage | Potential Side Effects |
| Oxybutynin chloride | Ditropan | Anticholinergic (antimuscarinic)/smooth muscle relaxant; tertiary amine | 15-30 mg daily | Dry mouth, blurry vision, constipation, tachycardia, drowsiness, dizziness |
| Oxybutynin chloride (OROS) | Ditropan XL | See above | 5-30 mg daily | See above, less CNS side effects |
| Transdermal oxybutynin | Oxytrol | See above | 3.9 mg/day patch | See above |
| Tolterodine | Detrol | Antimuscarinic/smooth muscle relaxant | 1-2 mg BID | See above |
| Tolterodine (long acting) | Detrol LA | See above | 2-4 mg Q day | See above |
| Trospium chloride | Sanctura | Antimuscarinic; quaternary amine | 20 mg BID | Dry mouth, constipation, headache |
| Darifenacin | Enablex | Antimuscarinic selective; tertiary amine | 7.5-15 mg Q day | Dry mouth, constipation, blurred vision |
| No CNS effects | ||||
| Imipramine hydrochloride | Tofranil | Tricyclic antidepressant: anticholinergic, alpha-adrenergic, antihistamine | 25-100 mg daily | Drowsiness, orthostatic hypotension, hepatic dysfunction, xerostomia |